达托霉素耐药分子机制研究进展  

Molecular mechanisms underlying daptomycin resistance

作　　者：廖国建[1] 彭希希 田俊 谢建平[2] Guojian Liao;Xixi Peng;Jun Tian;and Jianping Xie(Institute of Modern Biopharmaceuticals, School of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China;State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Institute of Modern Biopharmaceuticals, School of Life Sciences, Southwest University, Chongqing 400715, China)

机构地区：[1]西南大学药学院现代生物医药研究所,重庆400716 [2]西南大学生命科学学院现代生物医药研究所三峡库区生态环境与生物资源省部共建国家重点实验室培育基地,重庆400715

出　　处：《生物工程学报》2018年第6期832-838,共7页Chinese Journal of Biotechnology

基　　金：国家自然科学基金(Nos.31670050;31100069);中央高校基本科研业务费专项资金(No.XDJK2017B011)资助~~

摘　　要：环脂肽抗生素达托霉素抗菌活性强,致病菌不容易产生耐药性,已成为治疗革兰氏阳性菌特别是耐药菌感染的一线药物。但由于广泛使用,仍然出现了达托霉素耐药菌。细胞膜磷脂代谢和细胞壁结构动态与致病菌达托霉素耐药密切相关。文中综述了达托霉素作用机制和耐药机制,以期对药物研发和临床用药有所裨益。Due to potent bactericidal activity and low rate of drug-resistance, daptomycin is recognized as first line antibiotic to treat serious infections caused by drug-resistant Gram-positive pathogens. However, the incidence of daptomycin resistance is increasing due to its widespread application. Alteration of cell wall homeostasis and membrane phospholipid metabolism is involved in daptomycin resistance. The unique mode of action underlying daptomycin resistance in important pathogens, including Staphylococcus aureus and Enterococci, is presented in this paper.

关 键 词：达托霉素 耐药 磷脂代谢 细胞壁结构动态 

分 类 号：R969[医药卫生—药理学]