野艾蒿中1个新的倍半萜  

A new sesquiterpenoid from Artemisia lavandulaefolia

作　　者：丁林芬 杨桂梅 郭亚东 宋流东 刘佳 吴兴德[3] DING Lin-fen;YANG Gui-mei;GUO Ya-dong;SONG Liu-dong;LIU Jia;WU Xing-de(Yunnan Key Laboratory of Pharmacology for Natural Products, School of Pharmaceutical Science, Kunming Medical University, Kunming 650500, China;Haiyuan College, Kunming Medical University, Kunming 650101, China;State Key Laboratory of Phytochemistry and Plant Resources in Western China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China)

机构地区：[1]昆明医科大学药学院暨云南省天然药物药理重点实验室,云南昆明650500 [2]昆明医科大学海源学院,云南昆明650101 [3]中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,云南昆明650201

出　　处：《中草药》2018年第9期1995-1999,共5页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81773611;21402212);云南省教育厅科学研究基金指导性项目(2017z DX156)

摘　　要：目的研究野艾蒿Artemisia lavandulaefolia地上部分的化学成分。方法采用多种柱色谱技术进行分离和纯化,根据波谱数据鉴定化合物的结构。结果从野艾蒿95%乙醇提取物中分离得到11个化合物,分别鉴定为(4R,5R,7R,10R)-4-羟基-桉烷-2,11-二烯-1-酮(1)、5-表-桉烷-4(15)-烯-1β,6β-二醇(2)、桉烷-4(15)-烯-1β,6α-二醇(3)、3-氧代-桉烷-1,4,11(13)-三烯-12-羧酸甲酯(4)、11β,13-二氢珊塔玛内酯(5)、anthemidin(6)、东莨菪素(7)、丹皮酚(8)、咖啡酸乙酯(9)、espeletone(10)、(1R*,2S*,3S*,4S*)-薄荷烷-1,2,3,4-四醇(11)。结论化合物1为新化合物,命名为野艾蒿酮A;化合物2~11均为首次从该植物中分离得到。Objective To study the chemical constituents from the aerial parts of Artemisia lavandulaefolia. Methods The constituents were isolated and purified by various column chromatographic techniques, and their structures were identified by spectroscopic analysis. Results Eleven compounds were isolated from 95% ethanol aqueous extract of A. lavandulaefolia and the structures were identified as（4 R,5 R,7 R,10 R）-4-hydroxy-eudesma-2,11-dien-1-one（1）, 5-epi-eudesma-4（15）-ene-1β,6β-diol（2）, eudesma-4（15）-ene-1β,6α-diol（3）, methyl 3-oxo-eudesma-1,4,11（13）-trien-12-oate（4）, 11β,13-dihydrosantamarin（5）, anthemidin（6）, scopoletin（7）, paeonol（8）, ethyl caffeate（9）, espeletone（10）, and（1 R＊,2 S＊,3 S＊,4 S＊）-mentha-1,2,3,4-tetrol（11）. ConclusionCompound 1 is a new compound named artemilavanone A, and compounds 2—11 are isolated from this plant for the first time.

关 键 词：野艾蒿 倍半萜 野艾蒿酮A 5-表-桉烷-4(15)-烯-1β 6β-二醇 东莨菪素 espeletone 

分 类 号：R284.1[医药卫生—中药学]