藏药榜嘎中黄酮类化学成分的研究  

Study on flavonoids from Tibetan herb of Bangga

作　　者：兰钧 夏柯 李启发 阿萍 LAN Jun;XIA Ke;LI Qi-fa;A Ping(Tibet Institute for Food and Drug Control, Lhasa 850000, China;Chengdu Push Bio-Teehnology Co, Ltd. , Chengdu 610041, China)

机构地区：[1]西藏自治区食品药品检验研究院,拉萨850000 [2]成都普思生物科技股份有限公司,成都610064

出　　处：《药物分析杂志》2018年第6期964-972,共9页Chinese Journal of Pharmaceutical Analysis

基　　金：国家食品药品监督管理总局药化注册司专项：“12种特色民族药材检验方法的示范性研究”

摘　　要：目的:研究毛茛科乌头属植物榜嘎地上部分的黄酮类成分。方法:采用大孔吸附树脂富集,正相硅胶柱层析色谱法初分,通过葡聚糖凝胶Sephadex LH-20和半制备高压液相色谱法对各特征峰进行精制分离,根据其理化性质和NMR、MS等波谱数据鉴定化合物结构。结果:从榜嘎70%甲醇提取物中分离得到6个黄酮苷类化合物,分别鉴定为Clovin(1)、刺槐苷(2)、榜嘎苷A(3)、榜嘎苷B(4)、榜嘎苷C(5)、榜嘎苷D(6)。结论:化合物1、2为首次从榜嘎中分离得到,化合物3~6为新黄酮类化合物。Objective：To investigate the flavonoids in bangga,aerial part of Aconitum naviculare（Bruhl.）Stapf.Methods：The compounds were separated and purified by silica gel and Sephadex LH-20 gel column chromatography as well as pre-HPLC.Their structures were identified by spectral analysis and chemical methods.Results：Six compounds were isolated from the 70% methanol extract of bangga.On the basis of the spectral data,their structures were identified as Clovin（1）,robinin（2）,bangga flavonoid glycoside A（3）,bangga flavonoid glycoside B（4）,bangga flavonoid glycoside C（5）and bangga flavonoid glycoside D（6）.Conclusion：Compound 1 and compound 2 were isolated from bangga for the first time,and compound 3,4,5 and 6 were new flavonoids and named as bangga flavonoid glycoside A,bangga flavonoid glycoside B,bangga flavonoid glycoside C and bangga flavonoid glycoside D,respectively.

关 键 词：榜嘎 黄酮类化合物 clovin 刺槐苷 榜嘎苷A 榜嘎苷B 榜嘎苷C 榜嘎苷D 

分 类 号：R917[医药卫生—药物分析学]