病毒感染与鼻息肉关系的Meta分析  

The relationship between viral infection and nasal polyps:A Meta-analysis

作　　者：谭德重 冯源 胡月[2] 阎艾慧 TAN Dezhong;FENG Yuan;HU Yue;YAN Aihui(China Medical University, Liaoning Provincial Education Department, Shenyang, 110001, China;Department of Otolaryngology,First Affiliated Hospital of China Medical University)

机构地区：[1]中国医科大学,沈阳110001 [2]中国医科大学附属第一医院耳鼻咽喉科

出　　处：《临床耳鼻咽喉头颈外科杂志》2018年第12期910-916,共7页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨病毒感染与鼻息肉发生的关系,更好地理解鼻息肉的病因学和发病机制,为鼻息肉的预防和治疗提供科学依据。方法:系统检索Pubmed、Embase、Web of Science、Cochrane图书馆、中国期刊全文数据库、万方数字化期刊数据库、中国科技期刊全文数据库等数据库,文献检索时间为建库开始至2018年1月1日,全面检索国内外已公开发表的关于人乳头状瘤病毒(HPV)、EB病毒、呼吸道病毒感染与鼻息肉之间关系的病例对照研究相关文献,同时追溯纳入文献相关的参考文献,并获取全文。应用Stata 12.0分析软件对各原始数据进行统计处理,计算合并OR值及95%CI。结果:共纳入21篇文献,共有24个关于HPV病毒、EB病毒、呼吸道病毒感染与鼻息肉关系的研究。Meta分析结果显示,HPV感染与鼻息肉发生的OR值为6.74,95%CI为2.50-18.20,P<0.001,EB病毒与鼻息肉发生的OR值为5.15,95%CI为1.66-16.02,P=0.005,呼吸道病毒与鼻息肉发生的OR值为1.68,95%CI为0.93-3.03,P=0.087,皆无发表偏倚存在。结论:HPV、EB病毒感染与鼻息肉的发生密切相关,而呼吸道病毒感染与鼻息肉的发生无关,病毒感染可能为鼻息肉发生的病因学之一,在发病机制中起重要作用,在今后鼻息肉的防治过程中应该针对病毒感染进行早期干预。Objective：The relationship between viral infection and the occurrence of nasal polyps was explored to help us understand the etiology and pathogenesis of nasal polyps,and to provide scientific basis for the prevention and treatment of nasal polyps through a Meta-analysis.Method：By searching Pubmed,Embase,Web of Science,Cochrane Library,CNKI,Wanfang Database,and VIP Database,time starts from database building until January 1,2018,a comprehensive case-control study on the relationship between human papillomavirus,EpsteinBarr virus（EBV）,respiratory virus infection and nasal polyps published at home and abroad has been conducted.At the same time,relevant literature references have been included and the full texts have been obtained.Stata12.0 analysis software was used to perform statistical processing on each original data.Odds ratios（OR）and their95% confidence interval（CI）were adopted to assess the strength of association.Result：21 articles with 24 studies were included on the relationship between HPV,EBV,respiratory viral infection and nasal polyps.The Meta-analysis results showed that the ORof HPV infection and nasal polyps was 6.74,95%CI was 2.50-18.20,P0.001,the ORof EBV and nasal polyps was 5.15,95%CI was 1.66-16.02,P=0.005,the ORof respiratory viruses and nasal polyps was 1.68,95%CI was 0.93-3.03,P=0.087.There was no significant publication bias in all of the comparisons.Conclusion：HPV and EBV infection were closely associated with the nasal polyps.Respiratory viral infection was not associated with the nasal polyps.Viral infection may be one of the etiologies of nasal polyps.It plays an important role in the pathogenesis of nasal polyps.The prevention and treatment of the virus infection should be targeted at early intervention.

关 键 词：人乳头状瘤病毒 EB病毒 呼吸道病毒 鼻息肉 META分析 

分 类 号：R765.25[医药卫生—耳鼻咽喉科]