成体稳态造血的维持——造血干细胞还是造血祖细胞?  

Hematopoietic Stem Cells or Hematopoietic Progenitor Cells Maintain the Steady-State Hematopoiesis?——Editorial

作　　者：张珊珊 董芳 程涛 Hideo Ema ZHANG Shan-Shan;DONG Fang;CHENG Tao;EMA Hideo(State Key Laboratory of Experimental Hematology, Institute of Hematology ＆Blood Disease Hospital, Chinese Academy of Medical Sciences ＆Peking Union Medical College, Tianjin 300020, China;Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, Tianjin 300020, China;Department of Stem Cells and Regenerative Medicine, Peking Union Medical College, Tianjin 300020, China)

机构地区：[1]中国医学科学院北京协和医学院,血液病医院,血液学研究所,实验血液学国家重点实验室,天津300020 [2]中国医学科学院干细胞医学中心,天津300020 [3]北京协和医学院干细胞与再生医学系,天津300020

出　　处：《中国实验血液学杂志》2018年第3期637-641,共5页Journal of Experimental Hematology

基　　金：国家自然科学基金项目(81470279;81500085;81670105;81670106;81421002);科技部重大基础研究项目(2015CB964400);中国医学科学院;北京协和医学院协和青年基金项目(332015127;332015125);中国医学科学院医学与健康科技创新工程项目(2016-I-1-017)

摘　　要：造血干细胞(hematopoietic stem cell,HSC)一直被认为处于造血级联的顶端,通过维持自身的自我更新并逐级向下分化成熟,为机体源源不断地提供各种成熟的血细胞。基于HSC移植后分化成熟的变化规律为主要技术方法的研究表明,HSC维持着整个造血系统的稳定,并且在分化发育过程中存在多种不同的模型。然而,从根本上来讲这些研究结果反映的是HSC应对外界压力的应激反应,与正常稳态情况下HSC对于整个造血系统的维持作用并不相同。而最新的一系列利用不同的实验模型对造血祖细胞(hematopoietic progenitor cell,HPC)在造血稳态维持中的作用进行了研究,发现HPC才是造血稳态维持的"主力军"。本文将对目前存在争议的关于HSC和HPC在稳态造血系统维持中作用的最新研究进展作一评述。Current dogma suggests that hematopoietic stem cells（ HSC） reside in the top of the hematopoietic hierarchy,which can provide all kinds of mature blood cells constantly through self-renewal and multilineage differentiation potential.HSC has been regarded as the main cell population that maintains the stable hematopoiesis and several differentiation and development patterns of HSC have been summarized based on transplantation results.However,in deed the transplantation experiment is based on an extremely situation of stress which could not really reflect the function of HSC in normal homeostatic condition.Recent studies show that hematopoietic progenitor cells（ HPC） play the most important role in hematopoiesis based on different experimental strategies.This article focuses on the controversial subject of the function of HSC and HPC under homostasis.

关 键 词：造血干细胞 造血祖细胞 稳态造血 

分 类 号：R329.28[医药卫生—人体解剖和组织胚胎学]