胰岛素样生长因子Ⅰ型受体(IGF-IR)在MDS患者骨髓CD34阳性细胞中的表达  

Expression of Insulin-like Growth Factor Recepter Type Ⅰ in CD34^+ Cells of Patients with Myelodysplastic Syndromes

作　　者：张青霞 贺琪[2] 郭娟[2] 许峰[2] 张征[2] 杨莲萍[2] 常春康[2] ZHANG Qing-Xia;HE Qi;GUO Juan;CHANG Chun-Kang;XU Feng;ZHANG Zheng;YANG Lian-Ping(Department of Hematology, The East-Branch of Sixth People＇s Hospital, Shanghai Jiaotong University, Shanghai 201306, China;Department of Hematology, The Sixth People＇s Hospital, Shanghai Jiaotong University, Shanghai 200233, China)

机构地区：[1]上海市第六人民医院东院血液科,上海201306 [2]上海市第六人民医院血液科,上海202233

出　　处：《中国实验血液学杂志》2018年第3期849-853,共5页Journal of Experimental Hematology

摘　　要：目的:探讨骨髓增生异常综合征(MDS)患者CD34^+细胞表面胰岛素样生长因子I型受体(IGF-IR)的表达状况。方法:采用流式细胞术检测18例正常对照及100例MDS患者CD34^+细胞表面IGF-IR的表达。结果:100例MDS患者骨髓CD34^+细胞IGF-IR的平均表达率为(41.0±28.1)%,明显高于正常对照中的IGF-IR表达率(4.3±1.8)%(P<0.0001),其中22例高危组患者CD34^+细胞IGF-IR表达率较低危组(78例)明显增高[(66.5±27.8)%vs(34.5±24.9)%](P<0.0001);23例有染色体异常患者的CD34^+细胞的IGF-IR表达率较染色体正常组患者(77例)明显增高[(56.0±30.9)%vs(36.9±26.2)%](P<0.01)。结论:IGF-IR在MDS患者CD34^+细胞中过度表达,提示IGF-IR可能参与MDS的起源、发生及发展。IGF-IR在高危组及染色体异常组增高更明显,提示IGF-IR可能与细胞的恶性克隆增殖有关,有望为MDS患者的预后与转归的评估提供依据。Objective： To explore the expression level of insulin-like growth facter（ IGF-IR） in CD34-＋ cells of patients with myelodysplastic syndromes（ MDS）.Methods： Flow cytometry was used to detect the expression of IGF-IR in the CD34-＋ cells of 100 MDS patients and 18 normal controls.Results： The average IGF-IR expression level in the CD34-＋ cells of 100 MDS patients（41.0 ± 28.1） % was statistically and significantly elevated in comparison with the corresponding level in normal controls（4.3 ± 1.8） %,（ P〈0.0001）.The average expression level of 22 cases in high-risk groups was very significantly increased,compared with that in 78 cases of low-risk groups[（66.5 ± 27.8） % vs（34.5% ± 24.9） %]（P〈0.0001）,and the average expression level in 23 patients with chromosome abnormality was very significantly increased in comparison with that in rest 77 patients [（56.0 ± 30.9） % vs（36.9% ± 26.2） % ]（ P〈0.01）.Conclusion：The over-expression of IGF-IR in CD34-＋ cells of MDS patients suggests that the IGF-IR may involve in the origin,occurrence and progress.The average IGF-IR expression level is markedly elevated in high-risk groups and the patients who showed chromosome abnormality,this trend revealed that IGF-IR correlates with malignant clonal proliferation in MDS patients,thus providing a basis for their prognosis and outcome evaluation.

关 键 词：骨髓增生异常综合征 胰岛素样生长因子Ⅰ型受体 CD34阳性细胞 

分 类 号：R551.3[医药卫生—血液循环系统疾病]