胞红蛋白结构、功能及相关机制  

Structure, function and the related mechanism of cytoglobin

作　　者：周丹蕾 刘小平 罗爱芹[1] ZHOU DanLei;LIU XiaoPing;LUO AiQin(School of Life Science, Beijing Institute of Technology, Beijing 100081, China;Davis Heart and Lung Research Institute and Division of Cardiovascular Medicine, Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA)

机构地区：[1]北京理工大学生命学院,北京100081 [2]Davis Heart and Lung Research Institute and Division of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, The Ohio State University

出　　处：《中国科学：生命科学》2018年第6期630-639,共10页Scientia Sinica(Vitae)

基　　金：美国国立卫生研究院R01项目(批准号:R01-HL131941);俄亥俄州立大学医学院院长基金;国家留学基金委项目(CSC)资助

摘　　要：胞红蛋白(Cygb)是一种血红素蛋白,属于珠蛋白家族中的一员.Cygb主要在纤维母细胞、心肌细胞及血管平滑肌细胞中表达,其主要生理功能还不清楚.据文献报道,胞红蛋白可储存氧、去除活性氧毒性、参与胶原合成、代谢一氧化氮、抗纤维化、调控基因表达、转导信号、抗肿瘤、调节血压.本文重点对胞红蛋白的结构特性,主要功能及作用机制展开论述,并介绍了胞红蛋白与疾病的关系,以期为今后的研究提供理论基础.Cytoglobin（Cygb）is a hemeprotein belonging to the globin superfamily.It is mainly expressed in fibroblasts,cardiomyocytes and vascular smooth muscle cells.The main function of Cygb is unclear.It has been reported that Cygb is involved in oxygen storage,reactive oxygen species detoxification,collagen synthesis,nitric oxide（NO）metabolism,regulation of gene expression,signal transduction,anti-fibrosis,anticancer,and regulation of blood pressure.In this article,we mainly review its structure characteristics,physiological functions,reaction mechanism,and the relationship of Cygb with some diseases,hoping to provide theoretical basis for future research.

关 键 词：胞红蛋白 结构 功能 作用机制 

分 类 号：Q51[生物学—生物化学]