热力学体系的物理学特性与酶学机制的热力学原理  

Physical characteristics of complex thermal system and working mechanism of enzymes

作　　者：赵钦一[1] ZHAO QinYi(Medical Institute, CRRC, Beijing 100068, China)

机构地区：[1]中国康复研究中心医学研究所,北京100068

出　　处：《中国科学：生命科学》2018年第6期650-661,共12页Scientia Sinica(Vitae)

摘　　要：本文总结讨论了复杂热力学体系的特点与原理.在此基础上,修改了阿累尼乌斯公式,修改后酶学反应速率公式包含蛋白质构象变化的热力学参数.因而可以在理论上分析与确立蛋白质构象变化与酶活性之间的关系.在本理论体系中,酶的调节与酶的作用机制是蛋白质运动的不同体现,二者的基本原理是一致的.可以证明,酶催化过程中活化能的降低来源于酶与底物的结合能.理论表明基因互作现象是生物信息的热力学整合过程.综上所述,蛋白质热力学是分析任何生物功能与过程的基础与原理.This paper discusses the behaviors and thermodynamic principle of complex thermal systems.The equations of enzymatic kinetics are revised to incorporate the thermodynamic parameters of protein conformational state,so that the role of protein conformational change in enzymatic reaction can be analyzed thermodynamically.In addition,the genetic interactions during the informational flow from genome to biological functions are analyzed thermodynamically.Based on these,the working mechanisms of enzyme action and regulation are further interpreted from a thermodynamic point of view and are found to be fundamentally the same.For example,the decrease of activation energy in enzymatic reaction comes from the binding between substrate and enzyme.Finally,we conclude that protein thermodynamics is a theoretical foundation for all biological processes.

关 键 词：蛋白质 酶 调节 机制 体系 

分 类 号：Q55[生物学—生物化学]