cTnT和NT-proBNP联合检测在急性心肌梗死患者预后评估中的作用  

The role of combined detection of cTnT and NT-proBNP in evaluating prognosis of patients with acute myocardial infarction

作　　者：王海洋[1] 杨守忠[1] 许鹏飞[1] WANG Hai-yang;YANG Shou-zhong;XU Peng- fei.(Nanyang Affiliated Hospital of Zhengzhou University, Nanyang City Center Hospital, Nanyang 473000, Chin)

机构地区：[1]郑州大学附属南阳医院南阳市中心医院,河南南阳473000

出　　处：《中国实验诊断学》2018年第6期981-983,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探究cTnT和NT-proBNP联合检测在急性心肌梗死(AMI)患者预后评估中的作用。方法对符合本次研究标准的AMI患者(AMI组)及体检健康者(对照组)分别测定cTnT、NT-proBNP水平并进行比较分析;同时随访12个月内是否发生主要不良心血管事件(MACE),将AMI组患者分为MACE组(48例)和无MACE组(87例)进行比较,分析cTnT和NT-proBNP水平与AMI患者预后的关系。结果 AMI组和对照组一般因素(年龄、性别、吸烟等)均无明显差异性(P>0.05)。比较两组的cTnT、NT-proBNP水平,结果显示AMI组均高于对照组,有显著统计学意义(P<0.01)。135例AMI患者中,随访12月后有48例发生了主要不良心血管事件,87例未发生,MACE组的cTnT、NT-proBNP水平均高于无MACE组,具有统计学意义(P<0.05)。结论在AMI患者的诊断、预后评估中cTnT、NT-proBNP的联合检测显示了高度优越性,具有重要临床意义。Objective To explore the role of cardiac calcin T（cTnT）and amino terminal natriuretic peptide precursor（NT-proBNP）in evaluating the prognosis of patients with acute myocardial infarction（AMI）.Methods Acute myocardial infarction（AMI group）who treated in our hospital,as the research object were analyzed retrospectively,and normal heart function in the same period were selected as the control group,the concentration of cTnT and NT-proBNP in the AMI group and the control group measured and compared;Meanwhile,according to the occurrence of major adverse cardiovascular events（MACE）during the follow-up period（12 months）,the AMI group was divided into MACE group（48 cases）and no MACE group（87 cases）,analysis of the relationship between the level of cTnT and NT-proBNP and the prognosis of patients with AMI.Results There was no statistical difference between the general information（age,gender,smoke etc）of the AMI group and the control group（P〉0.05）;The levels of cTnT and NT-proBNP in group AMI was higher than those in control group,which has statistical significance（P〈0.01）.Among these 135 AMI patients,48 has MACE in one year,while 87 patients didn＇t,the levels of cTnT and NT-proBNP in the MACE group was higher than that in the no MACE group,and the difference was statistically significant（P 0.05）.Conclusion In the diagnosis and prognosis evaluation of AMI patients,the combined detection of cTnT and NT-proBNP shows high superiority and has important clinical significance.

关 键 词：急性心肌梗死 心肌钙蛋白T 氨基末端脑钠肽前体 预后 

分 类 号：R542.2[医药卫生—心血管疾病]