基于光声-光学相干层析成像的血流测量技术  

Blood Flow Measurementwith Photoacoustic Microscopy and Optical Coherence Tomography

作　　者：潘柳华[1,2] 张向阳 李中梁[1,2] 南楠[1] 步扬 陈艳[1,2] 王瑄[1,2] 王向朝 Pan Liuhua;Zhang Xiangyang;Li Zhongliang;Nan Nan;Bu Yang;Chen Yan;Wang Xuan;Wang Xiangzhao(Laboratory of Information Optics and Optoelectronic Technology, Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences, Shanghai 201800, China;University of Chinese Academy of Sciences, Beijing 100049, China;School of Science, Jiangnan University, Wuxi , Jiangsu 214122, China)

机构地区：[1]中国科学院上海光学精密机械研究所信息光学与光电技术实验室,上海201800 [2]中国科学院大学,北京100049 [3]江南大学理学院,江苏无锡214122

出　　处：《中国激光》2018年第6期218-224,共7页Chinese Journal of Lasers

基　　金：上海市科学技术委员会创新行动计划(15441905600); 广西高校光电信息处理重点实验室开放基金(KFJJ2016-04)

摘　　要：研究应用光声-光学相干层析成像(PA/OCT)双模式成像方法测量血流绝对速度和角度。在双模式成像方法中,利用光声相关谱方法测量血流速度在垂直于探测激光光束传播方向的速度分量,利用多普勒光学相干层析成像测量血流速度在平行于探测激光光束传播方向的速度分量,最终得到血流绝对速度和角度。在不同倾斜角度条件下,针对绝对速度为1mm·s^(-1)的血液样品,PA/OCT测得流速结果的标准差为0.02mm·s^(-1),测得的血流角度与实际样品倾斜角度的相关系数为0.997。实验结果表明,PA/OCT可用于测量血流绝对速度和角度。Absolute blood flow velocity and orientation are measured by a dual-mode imaging technology using photoacoustic microscopy and optical coherence tomography（PA/OCT）.The blood flow velocity perpendicular to the direction of the probe beam is measured by photoacoustic correlation spectroscopy.The blood flow velocity parallel to the direction of the probe beam is measured by the Doppler OCT.Then the absolute velocity and orientation of blood flow are obtained.For the same fluid sample with different tilt angles,the standard deviation of the absolute blood flow velocity which is 1 mm·s^-1 measured by PA/OCT is 0.02 mm·s^-1 and the correlation coefficient between the blood flow orientation measured by PA/OCT and the actual flow orientation is 0.997.The experimental results show that the PA/OCT is suitable for measuring absolute blood flow velocity and orientation.

关 键 词：医用光学 光学相干层析成像 光声成像 流速测量 

分 类 号：TN247[电子电信—物理电子学]