AMI患者血清S100A12水平与冠状动脉病变严重程度的关系  

Correlation between serum S100A12 level and severity of coronary artery lesions in patients with acute myocardial infarction

作　　者：吕晓佟 刘鑫 王雪 孙伟[2] 徐珊珊[2] 李来传[2] 史有奎[2] LV Xiaotong;LIU Xin;WANG Xue;SUN Wei;XU Shanshan;LI Laichuan;SHI Youkui(Weifang Medical University, Weifang, Shandong, 261042, China;Department of Emergency Medicine,Affiliated Hospital of Weifang Medical University)

机构地区：[1]潍坊医学院临床医学院,山东潍坊261042 [2]潍坊医学院附属医院急诊科

出　　处：《临床心血管病杂志》2018年第6期588-592,共5页Journal of Clinical Cardiology

摘　　要：目的:研究血清S100A12在急性心肌梗死(AMI)患者中的表达,并进一步探究S100A12水平与AMI患者冠状动脉(冠脉)病变严重程度的关系。方法:选取潍坊医学院附属医院2016-09-2017-12因胸部不适入住心内科并首次行冠脉造影术的患者167例,其中符合AMI诊断标准者为AMI组(92例),行急诊PCI,根据造影结果将其分为单支病变亚组(26例)、双支病变亚组(32例)、三支病变亚组(34例);余入院后行择期PCI,根据造影结果将其分为心绞痛(AP)组(42例)和正常对照(NC)组(33例)。收集所有研究对象的基本信息、临床资料,并计算Gensini评分,用ELISA法测定所有研究对象血清S100A12水平,并进行统计分析。结果:(1)对AMI组、AP组和NC组进行两两比较,AMI组血清S100A12水平明显高于AP组和NC组(P<0.05),AP组血清S100A12水平明显高于NC组(P<0.05)。(2)根据冠脉病变支数进行分组统计,结果显示,随着病变支数的增加,Gensini评分数逐渐增加,且血清S100A12水平也逐渐增加,即三支病变亚组Gensini评分和血清S100A12水平明显高于双支病变亚组、单支病变亚组(P<0.05),双支病变亚组Gensini评分和血清S100A12水平明显高于单支病变亚组(P<0.05)。(3)血清S100A12水平与Gensini评分、高敏C反应蛋白、肌酸激酶同工酶水平呈正相关(P<0.05)。结论:AMI患者血清中S100A12水平明显升高,且与冠脉病变支数和冠脉病变严重程度呈正相关,这对于预测AMI病情严重程度、指导其临床分级和治疗具有重要意义。Objective：In order to study the expression of serum S100A12 in patients with acute myocardial infarction（AMI）and further explore the relationship between S100A12 level and the severity of coronary artery lesions in patients with AMI.Method：From September 2016 to December 2017,167 patients who were admitted to the department of cardiology and underwent coronary angiography for the first time due to chest discomfort were selected.The patients who met the diagnostic criteria for AMI were AMI group（n=92）and underwent emergency PCI.The patients were divided into single-branch lesion group（n=26）,double-branch lesion group（n=32）and three-branch lesion group（n=34）according to the results of angiography.After admission,PCI was selected and divided into angina pectoris（AP）group（n=42）and normal control（NC）group（n=33）.The basic information and clinical data of all subjects were collected,and the gensini score was calculated.The serum s100a12 level of all subjects was determined by ELISA and analyzed statistically.Result：（1）Compared with AP group and normal control（NC）group,serum S100A12 level in AMI group was significantly higher than that in AP group and NC group（P〈0.05）,and serum S100A12 level in AP group was significantly higher than that in NC group（P〈0.05）.（2）According to the number of coronary artery lesions,the results showed that with the increase of the number of lesions,gensini score increased gradually,and serum S100A12 level also increased gradually,that is,the three lesions group score and serum S100A12 level was significantly higher than the two lesions group,single lesion group（P〈0.05）,double lesion group score and serum S100A12 water.（3）Serum S100A12 level was positively correlated with gensini score,hs-CRP and CK-MB（P〈0.05）.Conclusion：The level of S100A12 in serum of patients with AMI was significantly increased,and was positively correlated with the number of coronary artery lesions and the severity of coronary artery lesion

关 键 词：急性心肌梗死 S100A12 GENSINI评分 冠状动脉病变程度 

分 类 号：R542.2[医药卫生—心血管疾病]