无金属、温和条件下唑的选择性N-烯基化（英文）  

Stereoselective Vinylation under Mild Metal-Free Conditions to Synthesize N-Vinylazoles

作　　者：李爽 向恒 姜瑞航 居佳[2,3] 焦鹏冲 苑华磊[2,3] 孙宏滨 蔡华强 Li Shuang;Xiang Heng;Jiang Ruihang;Ju Jia;Jiao Pengchong;Yuan Hualei;Sun Hongbin;Cai Huaqiang(Department of Chemistry, Northeastern University, Shenyang 110819;Institute of Chemical Materials, China Academy of Engineering Physics, Mianyang 621900;New Material Research Center in Siehuan, Chengdu 610000)

机构地区：[1]东北大学理学院,沈阳110819 [2]中国工程物理研究院化工材料研究所,绵阳621900 [3]四川省新材料中心,成都610000

出　　处：《有机化学》2018年第6期1493-1499,共7页Chinese Journal of Organic Chemistry

基　　金：Project supported by the Sci-Tech Innovation Funds for Institute of Chemical Materials(No.KJCX-201502)~~

摘　　要：N-乙烯基唑化合物因其优异的生物活性,是医药、农药等领域中重要的活性中间体.以唑类化合物为原料,2,3-二溴丙酸甲酯为Michael受体,近室温无金属催化合成了22种具有反式烯烃基团的N-乙烯基唑化合物,其中包括15种新化合物.研究表明,该反应条件温和,普适性好,能够高效合成立体选择性的N-乙烯基唑化合物.A metal-free synthetic protocol for N-vinylazoles has been developed. Twenty-two structurally diversed N-vinylazoles including 15 new compounds are obtained with good to high yield at near room temperature, and all of products consist trans-alkene moieties with high stereoselectivity.

关 键 词：无金属 C-N偶联 烯基化 唑类 立体选择性 

分 类 号：O626[理学—有机化学]