中医药调节胰岛β细胞自噬的研究进展  

Research Progress on Regulation of Pancreatic β Cell Autophagy by Chinese Medicine

作　　者：林育[1] 王浩钰 黄嘉华 郑昊 范穗强 LIN Yu;WANG Haoyu;HUANG Jiahua;ZHENG Hao;FAN Suiqiang(Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510006, China;The First Clinical College of Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510006, China;Department of Traditional Chinese Medicine, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangdong Province, Guangzhou 510000, China)

机构地区：[1]广州中医药大学临床药理研究所,广东广州510006 [2]广州中医药大学第一临床医学院,广东广州510006 [3]广东药科大学附属第一医院中医科,广东广州510000

出　　处：《中国中医药现代远程教育》2018年第10期156-158,共3页Chinese Medicine Modern Distance Education of China

摘　　要：随着人们生活方式的改变,全球范围内糖尿病患者不断增加,目前已达4.25亿,防治形势十分严峻。目前已有的糖尿病治疗方法仍然存在诸多不尽如人意之处,无法与当前巨大的需求相适应。在糖尿病的发生和进展中,胰岛β细胞的损伤占有重要地位。随着对自噬研究的深入,调节胰岛β细胞自噬水平已逐步被认为是改善胰岛β细胞损伤的一个重要途径,寻找高效的、稳定的、可调节胰岛β细胞自噬的药物是一个可行的攻克糖尿病的方向。传统中医药是一个巨大且有待发掘的宝库,因此我们对目前中医药调节胰岛β细胞自噬的研究进行了系统梳理,以期为后续的中医药调节胰岛β细胞自噬研究提供参考。With the change of people＇s lifestyle, the number of people with diabetes in the world is on the increase. At present, it has reached 425 million. The situation is very grim. At present there are still many ways of treating diabetes which are not satisfactory and can not meet the current huge demand. In the occurrence and progression of diabetes, pancreatic β-cell damage plays an important role. With the deepening of autophagy research, regulating autophagy of pancreatic β-cells has gradually been considered as an important way to improve pancreatic β-cell injury. It is feasible to find efficient and stable drugs that can regulate autophagy of pancreatic β-cells overcome the direction of diabetes. Traditional Chinese medicine is a tremendous treasure trove to be explored.Therefore, we systematically sorted out the current studies on the regulation of islet β-cell autophagy by Chinese medicine in order to provide reference for the follow-up study of traditional Chinese medicine in the regulation of islet β-cell autophagy.

关 键 词：自噬 胰岛Β细胞 糖尿病 中医药 消渴 

分 类 号：R285[医药卫生—中药学]