电流感觉阈值测定发现早期糖尿病周围神经病变的应用探讨  

Applications of current perception threshold evaluations in discovering early diabetic peripheral neuropathy

作　　者：朴贞雅 王丽宏[1] 傅雪莲[1] 梁梅花[1] 车慧[1] Piao Zhenya;Wang Lihong;Fu Xuelian;Liang Meihua;Che Hui(Department of Endocrine and Metabolic Disease, the Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China)

机构地区：[1]哈尔滨医科大学附属第二医院内分泌代谢病科,150001

出　　处：《中国医师杂志》2018年第6期941-943,共3页Journal of Chinese Physician

基　　金：国家自然科学基金(81200593)~~

摘　　要：糖尿病神经病变是糖尿病常见的远期并发症之一,可以累及周围神经系统及中枢神经系统,其中以糖尿病周围神经病变(DPN)最为多见。糖尿病周围神经病变不仅可以造成患者肢体疼痛、麻木、活动受限,更可能因为感觉减退及缺失最终进展为足溃疡甚至截肢,严重影响糖尿病患者的生活质量并增加其病死率。有近半数DPN的患者没有任何临床症状,因此对于糖尿病周围神经病变的早期发现与诊断就尤为关键。电流感觉阈值(CPT)测定作为早期发现DPN的手段之一,因其非侵入性、操作简便、敏感度高,越来越得到重视。目前几乎没有文章总结CPT测定用于研究DPN与其危险因素之间的关系的应用情况,本文将电流感觉阈值测定的原理、优点以及其与糖尿病周围神经病变的关系综述如下。Diabetic neuropathy is one of the common long-term complications of diabetes, which occurs in the peripheral nervous system and the central nervous system, and its most common type is diabetic peripheral neuropathy （DPN）. Diabetic peripheral neuropathy can not only cause pain, numbness and limitation of activity in limbs, but also lead to diabetic foot ulcers even amputations due to hypoesthesia and anesthesia, ultimately affects the quality of life of patients with diabetes and increases the mortality. Nearly half of patients with DPN do not have any clinical symptoms, thus the early detection and diagnosis of diabetic peripheral neuropathy are particularly critical. Current perception threshold （CPT） evaluation is con- sidered as a mean of early detection of DPN, which gains more and more attentions because of its non-invasive feature, simple operation and high sensitivity. So far, there is scarcely any article summarizing CPT evaluations＇ applications in researching the relationships between DPN and its risk factors. This review will discuss the principles and advantages of CPT evaluations, and its relationship with DPN will also be summarized as follows.

关 键 词：经皮神经电刺激 感觉阈 糖尿病神经病变 周围神经系统疾病 综述 

分 类 号：R587.2[医药卫生—内分泌]