血清肿瘤标志物和自身抗体与肺癌患者临床病理特征的相关性研究  

Correlation research of serum tumor makers and autoantibodies with clinicopathological characteristics in lung cancer patients

作　　者：刘苗苗 南岩东[1] 陈艳丽[1] 谢永宏[1] 金发光[1] Liu Miaomiao, Nan Yandong, Chen Yanli, Xie Yonghong, Jin Faguang.(Department of Pulmonary and Critical Care Medicine, Tangdu Hospital, the Fourth Military Medical University,Xi′an 710038, Chin)

机构地区：[1]第四军医大学唐都医院呼吸科,西安710038

出　　处：《中华肺部疾病杂志（电子版）》2018年第2期176-181,共6页Chinese Journal of Lung Diseases(Electronic Edition)

基　　金：空军军医大学唐都医院骨干人才资助基金(No.2017-01)

摘　　要：目的探讨7项血清肿瘤标志物和7项自身抗体的表达水平与肺癌患者临床病理特征的相关性。方法收集我院治疗的65例肺癌患者,采用酶联免疫吸附实验法分别检测患者血清中7项肿瘤标志物和7项自身抗体的表达水平,进一步分析两者在不同肺癌病理类型及临床分期中表达的相关性。结果 7项肿瘤标志物中FRT、CYFRA21-1在不同年龄肺癌患者中的表达差异均具有统计学意义(P<0.05),NSE、CYFRA21-1在肺癌患者不同病理类型中的表达均具有明显的差异(P<0.05),P53在肺癌患者不同的临床分期中的表达水平具有差异(P<0.05);血清肿瘤标志物与自身抗体在非小细胞肺癌中呈正相关关系,在临床Ⅰ期中表现为负相关关系,在Ⅱ-Ⅳ期表现为正相关关系。结论 7项血清肿瘤标志物与7项自身抗体的有效联合检测对于不同肺癌类型患者具有辅助诊断的价值。Objective To study the correlation between the expression levels of seven serum tumor markers and seven autoantibodies and the clinicopathological features of lung cancer patients. Methods Sixtyfive newly diagnosed lung cancer patients were collected in our hospital. The expression levels of seven tumor markers and seven autoantibodies in the sera of patients were detected by enzyme-linked immunosorbent assay（ELISA）,and further the correlation of their expression levels with different lung cancer pathological types and clinical stages was analyzed. Results Significant differences were observed in the expression of FRT and CYFRA21-1 among the 7 tumor markers in patients with lung cancer at different ages（P〈0. 05）. The expression of NSE and CYFRA21-1 in different pathological types of lung cancer patients was significantly different（P〈0. 05）. In addition,P53 expression in lung cancer patients at different clinical stages exhibited obvious differences（P〈0. 05）. There was a positive correlation between serum tumor markers and autoantibodies in non-small cell lung cancers（NSCLC）; while negatively correlated in clinical stage I,and positively correlated with stages Ⅱ-Ⅳ. Conclusion Combined detection of seven serum tumor markers and autoantibodies has the value of adjuvant diagnosis for different types of lung cancer patients.

关 键 词：支气管肺癌 肿瘤标记物 自身抗体 联合检测 

分 类 号：R563[医药卫生—呼吸系统]