新颖的A_2BA_2型温敏(PNIPAM)_2-b-HTPB-b-(PNIPAM)_2嵌段共聚物的合成与自组装研究  

Synthesis and Self-assembly of a Novel A_2BA_2-type Themosensitive(PNIPAM)_2-b-HTPB-b-(PNIPAM)_2 Block Copolymers

作　　者：张新建[1] 罗延龄[2] 牛莉[1,2] 段贤勇[1] ZHANG Xin-jian 1 ,LUO Yan-ling 2 ,NIU Li 1,2 ,DUAN Xian-yong 1(1.Department of Mechanical Engineering,Anhui Technical College of Mechanical and Electrical Engineering,Wuhu 241000,China;2.School of Chemistry and Materials Science,Shaanxi Normal University,Xi’an 710062,Chin)

机构地区：[1]安徽机电职业技术学院机械工程系,安徽芜湖241002 [2]陕西师范大学材料科学与工程学院,陕西西安710062

出　　处：《塑料工业》2018年第5期48-53,共6页China Plastics Industry

基　　金：安徽高校自然科学研究重点资助项目(KJ2016A132);安徽省高校优秀青年人才支持计划重点项目(gxyq ZD2017103);安徽省承接教育部<高等职业教育创新发展行动计划(2015-2018年)>(XM-2;XM-6)

摘　　要：采用原子转移自由基聚合法(ATRP)合成了一类具有温敏性的A_2BA_2型嵌段聚合物,聚(N-异丙基丙烯酰胺)2-端羟基聚丁二烯(HTPB)-聚(N-异丙基丙烯酰胺)2[(PNIPAM)_2-b-HTPB-b-(PNIPAM)_2]。通过核磁共振仪(~1H NMR)、红外光谱仪(FTIR)和凝胶渗透色谱仪(GPC)对共聚物进行化学结构表征,确认了合成的目标产物。利用表面张力仪和紫外可见分光光度计对聚合物水溶液的临界胶束浓度(CMC)及低临界溶液温度(LCST)进行了测定,通过透射电子显微镜(TEM)及动态激光光散射技术(DLS)观测了其形态和尺寸。结果表明,合成的嵌段共聚物能够在水溶液中自组装成温敏响应性的纳米尺度胶束,胶束具有低于10 mg/L的CMC、相转变温度33.0~34.5℃、DLS流体力学直径小于150 nm,尺寸分布窄。这些物理化学性质对嵌段共聚物胶束作为药物释放的载体应用是非常有意义的。A thermo-sensitive A2BA2-typeblock copolymer was synthesized by a atom transfer free radical polymerization route（ATRP）,which is composed of hydroxyl-terminated polybutadiene（HTPB） and poly（N-isopropyl acrylamide）（PNI-PAM）,named（PNIPAM）2-b-HTPB-b-（PNIPAM）2.The copolymers were characterized and confirmed by -1H NMR,FTIR and GPC measurements.The critical micelle concentration（CMC） and low critical solution temperature（LCST） of the copolymers in aqueous solution was determined by surface tension meter and UV-vis spectrophotometer,and the morphology and size were observed by transmission electron microscope（TEM） and dynamic light scattering（DLS）.The experimental results show that the synthesized block copolymers can spontaneously assemble into thermo-responsive nanoscale micelle in aqueous solution,and the micelles have the CMC values less than 10 mg/L,phase transition temperature of 33.0 - 34.5 ℃,and hydrodynamic diameters less than 150 nm by DLS,and narrow size distribution.These physico-chemical properties make sense for the applications of block copolymer micelles as drug controlled release carriers.

关 键 词：生物材料 原子转移自由基聚合 嵌段共聚物 自组装 胶束化 

分 类 号：TQ316.322[化学工程—高聚物工业]