大环超分子二(三环己基锡)吡啶-二甲酸酯的合成、结构和抗癌活性  

Syntheses,Structures and in Vitro Antitumor Activity of Bis(tricyclohexyltin)Pyridinedicarboxylate with Macrocyclic Supramolecular Structure

作　　者：邝代治 庾江喜 冯泳兰 朱小明 蒋伍玖 张复兴 KUANG Dai-Zhi;YU Jiang-Xi;FENG Yong-Lan;ZHU Xiao-Ming;JIANG Wu-Jiu;ZHANG Fu-Xing(Key Laboratory of Functional OrganometaLlic Materials of Hengyang Normal University, College of Hunan Province,Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China)

机构地区：[1]衡阳师范学院化学与材料科学学院功能金属有机材料湖南省普通高等学校重点实验室功能金属有机化合物湖南省重点实验室,衡阳421008

出　　处：《无机化学学报》2018年第6期1035-1042,共8页Chinese Journal of Inorganic Chemistry

基　　金：湖南省高校创新平台开放基金(No.16K011);功能金属有机材料湖南省普通高校重点实验室开放基金(No.GN16K01);湖南省自然科学基金(No.13JJ3112)资助项目

摘　　要：在微波溶剂热中,三环己基氢氧化锡分别与2,6-H_2pydc和3,5-H_2pydc(H_2pydc=吡啶二甲酸)反应,合成了4个二(三环己基锡)吡啶-二甲酸酯:{[(2,6-Hpydc)SnCy_3]·MeOH}_n(1)、[(2,6-pydc)Sn_2Cy_6(H_2O)]·PhH(2)、[(3,5-pydc)Sn_2Cy_6(MeOH)]·MeOH(3)和[(3,5-pydc)Sn_2Cy_6(H_2O)]·EtOH(4)。对它们的组成和结构进行了元素分析、IR、(1H,13C和119Sn)NMR和单晶X射线衍射表征。化合物中心锡与配基原子构成畸形四、六面体构型,由于氢键作用,化合物形成二维大环网状超分子结构。初步探索了1、3对人结肠癌(HT-29)、肝癌细胞(HepG2)、乳腺癌(MCF-7)、鼻咽癌(KB)和肺癌细胞(A549)的增殖抑制活性,结果表明化合物具有广谱和较强的抗癌作用。Four bis（tricyclohexyltin）pyridinedicarboxylates, {[（2,6-Hpydc）SnCy3]·Me}n（1）, [（2,6-pydc）Sn2Cy6（H2O）]·Ph H（2）, [（3,5-pydc）Sn2Cy6（MeOH）]·MeOH（3） and [（3,5-pydc）Sn2Cy6（H2O）]·EtOH（4）, have been prepared by the microwave-assisted solvothermal reaction of tricyclohexyltin hydroxide with 2,6-H2pydc and 3,5-H2pydc（H2pydc=pyridinedicarboxylic acid）, respectively. Compounds 1-4 have been characterized by elemental, IR,（1H,13C and 119Sn） NMR and single crystal X-ray diffraction analyses. The distorted tetrahedral and trigonal bipyramid geometry is formed by the tin and ligand atoms. These compounds has a 2D network with macrocyclic supramolecular by the hydrogen bonding interaction of the neighboring molecule. The antitumor activity showed that compounds 1 and 3 have higher activities than cisplatin in HT-29, HepG2, MCF-7, KB and A549 cell line in vitro.

关 键 词：三环己基锡吡啶二甲酸酯 微波溶剂热合成 结构 体外抗肿瘤活性 

分 类 号：O614.432[理学—无机化学]