高血压动脉粥样硬化患者血清中APN和MIP-1a与颈动脉病变程度及心血管事件的关系  

Relationship between APN and MIP-1a in Serum of Hypertensive Patients with Atherosclerosis and the Degree of Carotid Artery Disease and Cardiovascular Events

作　　者：孙萍 周丽莉 张瑞丽 王征帆 盛家和 Sun Ping(Cancer Hospital Affiliated to Zhengzhou University ,Zhengzhou 45000)

机构地区：[1]郑州大学附属肿瘤医院,郑州450008

出　　处：《数理医药学杂志》2018年第6期801-803,共3页Journal of Mathematical Medicine

摘　　要：目的:探讨高血压动脉粥样硬化患者血清中APN和MIP-1a与颈动脉病变程度及心血管事件的关系。方法:选取某院2016年5~2017年5月期间,确诊为高血压合并颈动脉粥样硬化患者90例作为研究对象,所有患者均采用酶联免疫吸附法检测患者血清中APN和MIP-1a水平,探讨不同颈动脉病变程度患者血清中APN和MIP-1a水平,并采用logistics回归分析探讨患者心血管事件发生的危险因素。结果:APN高水平组患软斑块、复合斑块发生率为37.7%、33.3%,明显高于低水平组患者;MIP-1a高水平组患者软斑块、复合斑块发生率为40%、31.1%,明显高于低水平组患者;扁平斑块、硬斑块发生率分别为15.7%、13.7%,明显低于低水平组;APN高水平组患者内-中膜厚度、斑块面积分别为(2.2±1.2)mm、(2.7±1.1)cm2,明显高于对应低水平组患者,MIP-1a高水平组患者分别为(2.3±1.4)mm、(2.8±1.4)cm2,明显高于对应低水平组患者。APN(P=0.01)、MIP-1a(P=0.04)是患者心血管事件的独立风险因素。结论:高血压动脉粥样硬化患者血清中APN和MIP-1a与颈动脉病变程度及心血管事件的密切相关。Objective：To investigate the relationship between serum APN and MIP-1 ain in serum of hypertensive patients with atherosclerosis and the degree of carotid artery disease and cardiovascular events.Methods：90 cases of patients with hypertension complicated with carotid atherosclerosis treated in a hospital from May 2016 to May 2017 were selected as the research object.The serum levels of APN and MIP-1 awere detected by enzyme linked immunosorbent assay（Elisa）,and the levels of APN and MIP-1 ain patients with different degree of carotid artery disease were studied.The risk factors of cardiovascular events were analyzed by logistics regression analysis.Results：The incidence of soft plaque and composite plaque in the high level APN group（37.7%,33.3%）was significantly higher than that in the low level APN group.The incidence of soft plaque and composite plaque in the high level MIP-1 agroup（40%,31.1%）was significantly higher than that in the low level MIP-1 agroup.The incidence of flat plaque and hard plaque in the high level group（15.7%,13.7%）was significantly lower than that in the low level group.The IMT and plaque area in the high level APN group were（2.2±1.2）mm and（2.7±1.1）cm2,which were higher than those in the low level group,respectively.The IMT and plaque area in high level MIP-1 agroup were（2.3±1.4）mm and（2.8±1.4）cm2,which were significantly higher than low level group.APN（P=0.01）and MIP-1 a（P=0.04）were independent risk factors for cardiovascular events.Conclusion：Serum APN and MIP-1 ain hypertensive patients with atherosclerosis are closely related to the degree of carotid artery disease and cardiovascular events.

关 键 词：颈动脉超声检查 APN MIP-1a 心血管事件 

分 类 号：R446.1[医药卫生—诊断学]