绝经后女性冠心病患者趋化因子CCL5水平与冠状动脉病变程度的相关性  

Correlation between Chemokine CCL5 Levels and Lesion Degree of Coronary Artery Disease in Postmenopausal Women with Coronary Heart Disease

作　　者：钱芳 李华[2] 瞿秋红[1] 王育斌[1] Qian Fang(Department of Physiology and Pathophysiology, Medical College, Wuhan University of Science and Technology ,Wuhan 43006)

机构地区：[1]武汉科技大学医学院生理与病理生理学系,武汉430065 [2]武汉科技大学临床学院妇产科学教研室

出　　处：《数理医药学杂志》2018年第6期822-824,共3页Journal of Mathematical Medicine

基　　金：武汉科技大学青年科技骨干培养计划项目(编号:2013xz030)

摘　　要：目的:探讨绝经后女性冠心病患者趋化因子CCL5水平与冠状动脉病变程度的相关性。方法:以绝经后女性冠心病患者(CHD组,n=44)和健康志愿者(对照组,n=44)为研究对象,检测两组受试者血清CCL5、高敏C反应蛋白(hs-CRP)水平,冠状动脉造影检查并采用Gensini评分评价CHD组患者冠状动脉病变程度,临床症状分级采用加拿大心血管协会(CCS)分级法,分析CHD组血清CCL5、hs-CRP水平与病变程度及临床分级的相关性。结果:与对照组比较,CHD组血清CCL5((42.5±8.21)vs(88.1±10.21)μg/L,P<0.05)、hs-CRP((0.45±0.14)vs(5.42±2.13)mg/L,P<0.05)水平显著升高;CHD组血清CCL5、hs-CRP水平与病变血管数量、Gensini评分及CCS分级呈正相关(P<0.05);此外,血清水平CCL5与hs-CRP水平无显著相关性(P>0.05)。结论:绝经后女性冠心病患者CCL5水平升高,与冠脉病变程度及临床分级呈正相关,可作为冠脉病变程度预测和CHD筛查的血清学指标。Objective：To evaluate the relationship between chemokine CCL5 levels and lesion degree of coronary artery disease in postmenopausal women with coronary heart disease.Methods：Postmenopausal women with coronary heart disease（group CHD,n=44）and healthy volunteers（control group,n=44）were selected as subjects.Serum levels of CCL5 and high sensitive C reactive protein（hs-CRP）were measured in the two groups.Coronary angiography and Gensini score were used to evaluate the lesion degree of coronary artery disease in CHD group.The clinical symptoms were classified by the Canadian Cardiovascular Association（CCS）.The correlation between the levels of serum CCL5,hs-CRP,and degree of lesion,and the clinical grade in CHD group was analyzed.Results：Compared with the control group,The serum CCL5（（42.5±8.21）vs（88.1±10.21）μg/L,P〈0.05）,and the hs-CRP（（0.45±0.14）vs（5.42±2.13）mg/L,P〈0.05）of CHD group increased significantly.In CHD group,the levels of serum CCL5,hs-CRP was positively related with the amount of artery lesion in patients,Gensini score and theCCS classification.Furthermore,there was no significant correlation between the levels of serum CCL5 and hs-CRP（P〉0.05）.Conclusion：The level of CCL5 in postmenopausal women with coronary heart disease is increased,which is positively correlated with the lesion degree of coronary artery disease and clinical grade,which cam be used as a serological index for predicting the severity of coronary artery disease and screening for CHD.

关 键 词：心血管疾病 冠心病 高敏C反应蛋白 趋化因子CCL5 

分 类 号：R541.4[医药卫生—心血管疾病]