间充质干细胞治疗急性放射性损伤的研究  

Mesenchymal stem cells in the treatment of acute radiation-induced injury

作　　者：薛飞 黄平平[1] Xue Fei, Huang Pingping(Institute of Hematology ＆ Blood Diseases Hospital, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Tianjin 300020, Chin)

机构地区：[1]中国医学科学院北京协和医学院血液学研究所,天津300020

出　　处：《中华细胞与干细胞杂志（电子版）》2018年第2期120-124,共5页Chinese Journal of Cell and Stem Cell（Electronic Edition）

基　　金：中国医学科学院医学与健康科技创新工程经费资助(2017-I2M-1-016)

摘　　要：急性放射性损伤是组织损伤的一种重要类型,目前未有较理想的治疗方案。间充质干细胞(MSCs)能够多向分化、自我更新,且具有分泌多种细胞因子、抗炎、免疫调节等生物活性。其在促进组织修复的优势显而易见,而移植的时机、剂量长期以来莫衷一是。致瘤性等安全问题制约其临床研究的进一步开展。近年来,MSCs趋向于无细胞化移植取得了明显成效。这一研究新进展势必迎来急性放射性损伤治疗的新格局,本文对此研究现状及进展进行综述。Acute radiation injury is one of serious complication of exposure to irradiation,but there is still no effective means to prevent and treat it. However, mesenchymal stem cells（MSCs） are self-renewal and differentiating into various cell lineages. These cells possess attributes such as secreting a variety of cytokines, anti-inflammatory and immunosuppressive properties. The advantages of MSCs in tissue-repaired is conspicuous, but the timing and doses of transplants have been controversial. The safety problems such as tumorigenicity restrict clinical trials. Recently, the result of cell-free transplantation is fruitful, and the new situation definitely comes soon. This review summarizes and discusses recent advances on MSCs treating severe acute radiation.

关 键 词：间充质干细胞 放射损伤 细胞治疗 

分 类 号：R818[医药卫生—放射医学]