动态血糖监测下超短效与短效胰岛素经胰岛素泵皮下输注治疗2型糖尿病的疗效比较  

A comparative study on dynamic blood glucose monitoring on the efficacy of infusion of ultra short-acting insulin and infusion of short-acting insulin by subcutaneous insulin pump in treatment of patients with type Ⅱ diabetes mellitus

作　　者：王艳 田园 李亚莉[2] WANG Yan;TIAN Yuan;LI Ya - li(Department of Internal Medicine, The First People＇s Hospital of Dongcheng District of Beijing , Beijing 100075, China;Department of Thoracic Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China)

机构地区：[1]北京市东城区第一人民医院内科,北京100075 [2]首都医科大学附属北京友谊医院胸外科,北京100050

出　　处：《临床和实验医学杂志》2018年第12期1305-1308,共4页Journal of Clinical and Experimental Medicine

基　　金：北京市东城区卫生局2013年中医发展项目(编号:DWZ2013-76)

摘　　要：目的观察临床应用动态血糖监测超短效与短效胰岛素经胰岛素泵皮下输注治疗2型糖尿病的效果。方法采用前瞻性研究方法选取2016年3月至2017年5月收治的104例2型糖尿病患者,随机分为对照组和观察组各52例。对照组患者给予短效胰岛素经胰岛素泵皮下输注治疗,观察组则应用超短效胰岛素进行治疗。对比分析两组患者的血糖控制指标、动态血糖监测指标、血糖达标时间、胰岛素用量及不良反应发生情况。结果治疗前,两组患者空腹血糖(FPG)、睡前血糖以及餐后2 h血糖(2 h PG)水平比较,差异无统计学意义(P>0.05);治疗后,两组各指标均较治疗前明显下降(P<0.05),组间比较,差异无统计学意义(P>0.05)。治疗前,两组患者血糖均值、血糖标准差、血糖≥10.0 mmo L以及血糖≤3.9 mmo L时间百分比比较,差异无统计学意义(P>0.05);治疗后,两组患者血糖均值、血糖标准差、血糖≥10.0 mmo L时间百分比均较治疗前明显下降(P<0.05),血糖≤3.9 mmo L时间百分比则明显升高(P<0.05);组间比较,观察组血糖均值、血糖标准差、血糖≤3.9 mmo L时间百分比明显低于对照组(P<0.05),两组血糖≥10.0 mmo L时间百分比则差异无统计学意义(P>0.05)。观察组患者血糖达标所用时间以及胰岛素用量均明显少于对照组,差异有统计学意义(P<0.05)。两组患者治疗期间均未见明显不良反应。结论经动态血糖监测发现超短效胰岛素经胰岛素泵皮下输注治疗2型糖尿病效果优于短效胰岛素,安全性高,可在临床推广应用。Objective To observe the efficacy of transient glucose monitoring and short acting insulin with subcutaneous insulin pump to treat patients with type 2 diabetes mellitus. Methods A prospective study was conducted. A total of 104 patients with type 2 diabetes mellitus were selected during March 2016 to May 2017. They were randomly divided into control group and observation group,each with 52 cases. Patients in control group were treated with short acting insulin with subcutaneous infusion by insulin pump,while patients in observation group were treated with ultrashort acting insulin. The blood glucose control index,dynamic blood glucose monitoring index,blood glucose standard time,insulin dosage and adverse reactions were compared between these two groups. Results Before treatment,two groups of patients with the levels of fasting blood glucose（ FPG）,bedtime blood glucose and 2 h postprandial blood glucose（ 2 h PG）,and the difference was not statistically significant（ P〉0. 05）. After treatment,these levels of patients in these two groups were significantly decreased compared with those before treatment（ P〈0. 05）,in comparison between groups,the difference was not statistically significant（ P〉0. 05）. Before treatment,in comparison with these two groups in blood levels of glucose,blood glucose mean standard deviation was greater than 10 mmo L and blood level of glucose was less than 3.9 mmo L There was no statistically significant difference（ P〉0. 05） in perccentage of times; after treatment,two groups of patients with blood glucose and blood glucose mean standard deviation was greater than 10 mmo L the percentage of times were significantly lower than those before treatment（ P〈0. 05）,and the percentage of times is less than 3. 9 mmo L increased significantly（ P〈0. 05）. In comparison among groups,the mean blood glucose,blood glucose,blood glucose standard deviation in observation group was less than 3. 9 mmo L the percentage of times was significantly lower than that of con

关 键 词：糖尿病 超短效胰岛素 短效胰岛素 胰岛素泵皮下输注 动态血糖 

分 类 号：R587.1[医药卫生—内分泌]