纳布啡和舒芬太尼分别复合丙泊酚用于门诊无痛胃肠镜检查的临床观察  

Nalbuphine and sufentanil combined with propofol for clinical observation were painless gastrointestinal endoscopy

作　　者：杨鹤[1] 刘缚鲲[1] 郑莉[1] 张晔[1] YANG He;LIU Fu - kun;ZHENG Li;et al.(Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China)

机构地区：[1]首都医科大学附属北京友谊医院麻醉科,北京100050

出　　处：《临床和实验医学杂志》2018年第12期1340-1343,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的比较丙泊酚分别复合舒芬太尼和两种剂量的纳布啡用于无痛胃肠镜检查的临床效果,并探讨纳布啡用于胃肠镜检查的最适剂量。方法选2016年1~3月于北京友谊医院行无痛胃肠镜的患者90例进行前瞻性研究,随机数法分为3组:舒芬太尼组(S组)、低剂量纳布啡组(N1组)、高剂量纳布啡组(N2组),每组各30例。S组静脉注射舒芬太尼0.1μg/kg,N1组静脉注射盐酸纳布啡0.1 mg/kg,N2组静脉注射盐酸纳布啡0.2 mg/kg。各组均静脉注射丙泊酚1.5~2.0 mg/kg,行胃镜加肠镜检查,术中酌情追加丙泊酚0.5~1.0 mg/kg,观察3组患者术中呼吸及生命体征变化程度、苏醒时间、视觉模拟评分(VAS)及术中体动情况。结果与N1组和N2组比较,S组术中呼吸频率减少最明显(P<0.05),3组在VAS评分和苏醒时间上差异无统计学意义(P>0.05)。结论盐酸纳布啡适宜在无痛胃肠镜检查中使用,0.1 mg/kg的剂量能够满足胃肠镜检查的要求且具有良好的安全性。Objective To compare the clinical effects of propofol combined with sufentanil and two doses of Nalbuphine in the painless gastrointestinal endoscopy,and to explore the optimal dosage of Nalbuphine in gastrointestinal endoscopy. Methods 90 patients were divided into3 groups（ n = 30） by the random number method： group S received Suffentanil 0. 1 μg/kg; group N1 received Nalbuphine 0. 1 mg/kg and group N2 received Nalbuphine 0. 2 mg/kg. Propofol 1. 5 ~ 2 mg/kg were then injected. Then gastrointestinal endoscopy was started. Intermittent intravenous boluses of Propofol 0. 5 ~ 1 μg/kg was given during operation when necessary. The breathing rate and other vital signs were observed. The awakening time and score of VAS at awakening were evaluated. Results There was no significant difference in awakening time and the score of VAS at awaking. The decrease of breathing rate is higher in group S than that in group N1 and group N2. Conclusion Nalbuphine is appropriate for use in pain-free gastrointestinal endoscopy,and the most suitable dosage is 0. 1 mg/kg.

关 键 词：无痛胃肠镜检查 纳布啡 舒芬太尼 丙泊酚 静脉全麻 

分 类 号：R614[医药卫生—麻醉学]