“靳三针”结合持续有氧运动对慢性应激抑郁模型大鼠的干预作用  

Effects of Jinsanzhen acupuncture combined with continuous aerobics on the rat model with chronic stress-induced depression

作　　者：蒋静娴 陈大贵 栾洁[2] 刘卫红 汪家春[2] Jiang Jingxian;Chen Dagui;Luan Jie;Liu Weihong;Wang Jiachun(Changzhou Food and Drug Control Center For,Jiangsu Province,Changzhoo 213002, China)

机构地区：[1]江苏省常州市食品药品监督检验中心,江苏常州213002 [2]海军医学研究所

出　　处：《海军医学杂志》2018年第2期125-128,共4页Journal of Navy Medicine

摘　　要：目的观察"靳三针"结合持续有氧运动对抑郁模型大鼠的作用。方法采用慢性轻度不可预见性的刺激建立大鼠慢性应激抑郁模型(chronic unpredicted mild stress,CUMS),30只模型大鼠随机分为3组,分别为正常对照组,模型组和治疗组,每组10只。模型组每天上午给予大鼠刺激;治疗组每天上午给予大鼠刺激,每天下午将大鼠置于跑步机,进行30 min跑步训练,并使用"靳三针"疗法进行治疗;正常对照组常规喂养,4周后进行各项指标检测。结果与模型组大鼠相比[(18.10±9.48)s、(7.00±4.78)次],"靳三针"结合有氧训练组大鼠跳台潜伏期增加[(29.50±13.43)s]、错误次数减少[(2.60±1.35)次](P<0.05);旷场水平、垂直得分均有所增加(P<0.05);水迷宫潜伏期减少、穿越站台次数增加(P<0.05);病理、电镜和尼氏结果显示"靳三针"结合有氧训练对模型大鼠脑组织有一定改善作用。结论 "靳三针"结合持续有氧运动对慢性应激诱导的大鼠抑郁具有一定的治疗作用。Objective To observe the therapeutic effects of Jinsanzhen acupuncture combined with continuous aerobics on the rats with chronic stress-induced depression. Methods The chronic stress-induced depression rat model was developed by using chronic unpredicted mild stimulation（ CUMS）. Thirty male SD rats were randomly divided into the normal control group,the model group（ or the experimental group） and the treatment group. The rats in the normal control group were given normal feed,but the rats of the model group received stimulation every morning,and the rats of the treatment group also received stimulation every morning,except that they were placed on the treadmill for 30-minute running exercise every afternoon,and then,they were treated with Jinsanzhen acupuncture.Four weeks later,various indicators were detected in the rats of all the groups. Results As compared with that of the rats in the model group,the platform-jumping latency of the rats in the Jinsanzhen therapy combined with continuous aerobics group was elevated,and the number of errors was decreased（ P〈0. 05）,open field horizontal and vertical scores were all increased to certain extents（ P〈0. 05）,the latency of water maze was decreased and the number of passing through the platform were increased（ P〈0. 05）. Pathologic,electron microscopic and Nissl detection results indicated that Jinsanzhen acupuncture combined with continuous aerobics could produce certain effects on the brain tissue of the model group. Conclusion Jinsanzhen acupuncture combined with continuous aerobic exercise could produce good effects on the rats with chronic stress-induced depression.

关 键 词：靳三针 有氧运动 行为学 大鼠 

分 类 号：R543[医药卫生—心血管疾病]