江苏省部分地区结核潜伏性感染影响因素研究  

Analysis of factors affecting latent tuberculosis infection in partial areas of Jiangsu province

作　　者：孔雯[1] 刘巧[1] 卢鹏 丁晓艳[1] 竺丽梅[1] 陈诚[1] 陆伟[1] KONG Wen;LIU Qiao;LU Peng;DING Xiao-yan;ZHU Li-mei;CHEN Cheng;LU Wei(Jiangsu Provincial Center for Disease Control and Prevention,Jiangsu Nanjing 210009 ,China)

机构地区：[1]江苏省疾病预防控制中心,江苏南京210009

出　　处：《江苏预防医学》2018年第3期244-246,共3页Jiangsu Journal of Preventive Medicine

基　　金：国家科技重大专项(2013ZX10003004-002-004)

摘　　要：目的研究江苏省非结核病人群中结核潜伏性感染(LTBI)现状及影响因素,为制定防治策略提供依据。方法选取江苏省丹阳市某镇2个村非活动性肺结核常住人口进行问卷调查、胸部X光片检查、空腹血糖检测和结核菌素试验,分析研究对象年龄、职业、慢性基础疾病等因素对非结核病人群结核分枝杆菌潜伏感染的影响。结果共纳入5 221例非结核病志愿者,检出结核分枝杆菌潜伏感染者2 015例,感染率38.6%。年龄、性别、卡痕、高血压病史、肝炎病史等因素与非结核病人群结核杆菌潜伏感染的发生均有统计学关联(P值均<0.05)。多元logistic分析显示,年龄>41岁(P值均<0.05)、女性(OR=0.690;95CI:0.615~0.775;P<0.001)、农民(OR=1.353;95CI:1.133~1.616;P=0.001)、肝炎病史(OR=1.576;95CI:1.079~1.846;P=0.019)以及糖尿病(OR=1.384;95CI:1.037~1.846;P=0.027)是该地区非结核病人群结核分枝杆菌潜伏感染的影响因素。结论丹阳市非结核病人群结核分枝杆菌潜伏性感染率达38.6%,应重点关注<41岁、男性及职业为农民、糖尿病患者及有肝炎病史的高危潜伏感染人群。Objective To study current latent tuberculosis infection（LTBI）and influential factors among non-TB population in Jiangsu province;to provide basis for making prevention and control strategies.Methods Non-TB residents of 2 villages in Danyang city of Jiangsu province were selected to conduct questionnaire surveys,chest X-rays,fasting blood-glucose and tuberculin tests.The influences of age,occupation and chronic diseases on LTBI of among non-TB population were analyzed.Results A total of 5 221 non-TB volunteers were recruited,among whom 2015 were LTBI,resulting the LTBI rate of38.6%.Age,gender,scar,history of hypertension,history of hepatitis were statistically correlated with the incidence of LTBI among non-TB population（all P0.05）.Multivariate logistic analysis showed age41 years old（all P0.05）,woman（OR=0.690;95 CI：0.615-0.775;P0.001）,farmer（OR=1.353;95 CI：1.133-1.616;P=0.001）,history of hepatitis（OR=1.576;95 CI：1.079-1.846;P=0.019）and diabetes（OR=1.384;95 CI：1.037-1.846;P=0.027）were influential factors for LTBI among non-TB population in local region.Conclusion The rate of LTBI among non-TB population in Danyang is 38.6%.Residents younger than 41 years old,male,farmer,with history of hepatitis and diabetes were high risk LTBI population,who required more attention in the future.

关 键 词：结核分枝杆菌 潜伏感染 糖尿病 危险因素 

分 类 号：R52[医药卫生—内科学]