2015-2016年我国北方沿海地区散发性戊型肝炎的流行病学、临床特点及危险因素分析  

Epidemiology,clinical features and risk factors of sporadic hepatitis E in the coastal regions in north China

作　　者：卜秋宁 李军良[1] 沈薇薇 杨丹丹 BU Qiuning;LI Junliang;SHEN Weiwei;YANG Dandan(Department of Clinical Laboratory, First Hospital of Qinhuangdao, Qin- huangdao 066600, Chin)

机构地区：[1]秦皇岛市第一医院检验科,秦皇岛066600

出　　处：《山西医科大学学报》2018年第5期460-463,共4页Journal of Shanxi Medical University

摘　　要：目的调查我国北方沿海地区散发性戊型肝炎的流行病学和临床特点,分析其潜在的危险因素。方法收集2015-01~2016-12我院就诊患者中血清HEV-Ig M和/或Ig G抗体阳性并确诊为戊型肝炎患者的临床资料,分析其流行病学和临床特点。结果 2015-2016年间,我院进行血清HEV-Ig M和Ig G抗体检测患者1 019例,诊断为戊型肝炎共127例。男性发病率较高(86/127,67.7%);平均年龄56.3岁。患者主要症状为黄疸(102/127,80.3%)、厌食(90/127,70.8%)、恶心(82/127,64.6%)和乏力不适(77/127,60.6%)。44例合并肝病基础,包括HBV共感染37例。17例合并糖尿病、心脏病等其他疾病。合并肝病基础的患者症状较重,肝功能损伤较严重。结论散发性戊型肝炎全年均可发生,无明显的季节性,老年人及合并基础疾病可能是HEV感染预后严重的主要危险因素。Objective To investigate the epidemiological and clinical features of sporadic hepatitis E（ HE） in the northern coastal areas of China and analyze the potential risk factors. Methods The patients with positive anti-HEV Ig M/Ig G and diagnosed as hepatitis E in our hospital from January 2015 to December 2016 were enrolled. Epidemiological characteristics and clinical profiles were analyzed. Results From 2015 to 2016,serum samples in 1 019 patients were detected for anti-HEV Ig M/Ig G. Among 1 019 cases,127 cases were confirmed as acute hepatitis E. Of these 127 patients,86（ 67. 7%） were male. The median age was 56. 3 years. The most common clinical presentations were jaundice（102/127,80%）,anorexia（ 90/127,71%）,nausea（ 82/127,64. 6%）,and malaise（ 77/127,60. 6%）. Among 44 patients with previous liver disease,37 were found co-infection with HBV. A total of 17 cases had a previous medical history for heart disease,diabetes and other diseases. The clinical course of HE patients with pre-existing liver diseases was severe,and the liver function injury was more serious. Conclusion Sporadic HE can occur throughout the year,without obvious seasonal occurrence. Aging and pre-existing diseases may be the principal risk factors for severe outcome of HEV infection.

关 键 词：戊型肝炎 戊型肝炎病毒 流行病学 

分 类 号：R181.3[医药卫生—流行病学]