青果氯仿萃取部位的化学成分研究  

Study on the Chemical Constituents in the Chloroform Extract of Fructus Canarii

作　　者：杨洛萍 孟涵 谭穗懿[1] 陈金香[1] 段文军[1] YANG Luoping;MENG Han;TAN Suiyi;CHEN Jinxiang;DUAN Wenjun(School of Pharmacy,SouthernMedical University,Guangzhou 510515,China;School of TCM,Southern Medical University,Guangzhou510515,China)

机构地区：[1]南方医科大学药学院,广州510515 [2]南方医科大学中医药学院,广州510515

出　　处：《中国药房》2018年第10期1340-1343,共4页China Pharmacy

基　　金：国家自然科学基金资助项目(No.81772194;41376162);广东省大学生创新创业训练计划项目(No.粤教高函[2015]113号);广州市科技计划项目(No.2014J4100159)

摘　　要：目的:研究青果氯仿萃取部位的化学成分。方法:采用小孔吸附树脂、Toyopear1 HW-40F凝胶树脂、反相C_(18)、Sephadex LH-20凝胶树脂柱对青果氯仿萃取部位进行分离纯化,根据理化性质和波谱数据(质谱、氢谱、碳谱)分析鉴定化合物结构。结果:从青果氯仿萃取部位中分离得到8个化合物,分别鉴定为二氢红花菜豆酸3′-O-β-D-葡萄糖苷(1)、3,4-二羟基苯甲酸(2)、3-O-没食子酰奎尼酸(3)、没食子酸(4)、没食子酸乙酯(5)、东莨菪内酯(6)、鞣花酸-4-O-α-L-吡喃鼠李糖苷(7)、异柯里拉京(8)。结论:化合物1、2、7为首次从青果中分离得到;该研究为青果的质量评价奠定了一定基础。OBJECTIVE：To study the chemical constituents in the chloroform extract of Fructus Canarii. METHODS：The chloroform extract of Fructus Canarii was isolated and purified by MCI,Toyopearl HW-40 F,reverse-phase C（18）,Sephadex LH-20 column. The structure of compounds was analyzed and identified by physicochemical properties and spectral data（mass spectrum,hydrogen spectrum and carbon spectrum）. RESULTS：Eight compounds were isolated from chloroform extract of Fructus Canarii,namely Dihydrophaseicacid-3′-O-β-D-glucopyranoside（1）,3,4-Dihydroxybenzoic acid（2）,3-O-galloylquinic acid（3）,Gallic acid（4）,Ethyl gallate（5）,Scopoletin（6）,Dllagic acid-4-O-α-L-rhamnopyranoside（7） and Isocorilagin（8）. CONCLUSIONS：Compounds 1,2 and 7 were firstly obtained from Fructus Canarii. The study lays foundation for quality evaluation of Fructus Canarii.

关 键 词：青果 化学成分 二氢红花菜豆酸3′-O-β-D-葡萄糖苷 3 4-二羟基苯甲酸 鞣花酸-4-O-α-L-吡喃鼠李糖苷 结构鉴定 氯仿萃取部位 

分 类 号：R284.1[医药卫生—中药学]