妊娠期代谢性疾病与运动介导的内质网自适应机制  

Adaptive Mechanism of Endoplasmic Reticulum by Gestational Metabolic Diseases and Exercise Mediated

作　　者：朱小烽[1,2] 马云[1] 叶群 梁辰[1] 傅姗 ZHU Xiao-feng 1,2, MA Yun1, YE Qun1,3, LIANG Chen1, FU Shan1,4(1 .National Reserch Institate of Sport Medicine,Beijing 100061, China; 2Jiaxing University, Zhejiang 314000, China; 3.Shanghai University of Sport,Shanghai 200438, China; 4.Wenzhou Medical University, Zhejiang 325035, China)

机构地区：[1]国家体育总局运动医学研究所,北京100061 [2]嘉兴学院师范学院,浙江314000 [3]上海体育学院运动科学学院,上海200438 [4]温州医科大学体育与健康学院,浙江325035

出　　处：《中国体育科技》2018年第3期68-78,115,共12页China Sport Science and Technology

基　　金：国家体育总局政府性基金资助项目(109031000000015J001);嘉兴市科技计划项目(2017AY33078)

摘　　要：孕期代谢性疾病的共同特征是胰岛素抵抗发展为病理性的糖脂代谢紊乱,再进而导致血管内皮损伤、胎盘炎症和氧化应激状态增加。各种内源性和外源性细胞损伤都将引起内分泌器官(如胰腺和胎盘)的内质网应激。这种机体内环境受损可能会导致"胎儿编程"易感性,使得将来发展为代谢性疾病的风险增加。为了适应孕期代谢应激,运动可以刺激内质网实现新的代谢平衡。适宜的运动可以减轻氧化应激、炎症反应、线粒体功能障碍和钙离子失衡,这可能是重建孕期代谢性疾病中内质网平衡的潜在机制。Gestational metabolic diseases share a common feature, which is the development of insulin resistance to pathological glucose and lipid metabolism disorders. It has thus led to vascular endothelial injury, placental inflammation and aggravated oxidative stress.. A variety of endogenous and exogenous cell damage will induce endoplasmic reticulum stress in endocrine organs, such as pancreas and placenta. Such damage to the internal environment of the body may lead to fetal programming susceptibility, thus adding to the risk of future development into metabolic diseases. Exercise can stimulate the endoplasmic reticulum to achieve a new metabolic balance, so as to adapt to the gestational metabolic stress. Appropriate exercise can alleviate oxidative stress, inflammatory response,mitochondrial dysfunction and calcium ion imbalance, which may account for the underlying mechanism of reconstructing endoplasmic reticulum balance in gestational metabolic diseases

关 键 词：妊娠期糖尿病 内质网应激 先兆子痫 运动适应 

分 类 号：G804.7[文化科学—运动人体科学]