2015年华东地区梅毒感染孕产妇人群特征分析  

Characteristics of syphilis-infected pregnant women in East China in 2015

作　　者：薛艳萍[1] 窦丽霞[1] 王爱玲[1] 王潇滟[1] 王前[1] 乔亚萍[1] 苏敏[1] 李珍 金曦[1] XUE Yan Ping;DOU Li Xia;WANG Ai Ling;WANG Xiao Yan;WANG Qian;QIAO Ya Ping;SU Min;LI Zhen;JIN Xi(National Centre for Women and Children＇ s Health, China CDC, Beijing 100081, China)

机构地区：[1]中国疾病预防控制中心妇幼保健中心,北京100081

出　　处：《中国妇幼卫生杂志》2018年第3期1-4,共4页Chinese Journal of Women and Children Health

摘　　要：目的了解华东地区梅毒感染孕产妇的感染特征并探讨相关影响因素。方法利用2015年我国华东地区预防艾滋病、梅毒和乙肝母婴传播管理信息系统中梅毒感染孕产妇监测数据,对孕产妇的人口学特征、感染特征和非梅毒螺旋体抗原血清学试验滴度(非梅滴度)水平进行描述,利用Logistics回归模型对非梅滴度的影响因素进行分析。结果 2015年我国华东地区共发现9101例梅毒感染孕产妇。孕早期接受过产前检查的孕产妇4613例(50.7%),而妊娠梅毒诊断时期为孕早期者仅有2805例(30.8%)。梅毒感染途径不详的孕产妇有5640例(62.0%)。有5954例(65.4%)孕产妇的丈夫/性伴感染状态不详。孕产妇高非梅滴度(≥1∶8)水平同年龄、婚姻状态、教育程度、初检孕周、既往梅毒感染史,以及丈夫/性伴感染状态之间存在关联。结论梅毒感染孕产妇妊娠期梅毒诊断存在延误现象,并且存在再次感染风险。建议进一步优化预防梅毒母婴传播干预服务流程,规范咨询、诊疗和随访服务,加强性伴检测,从而有效降低先天梅毒发病风险。Objective To understand the infection-related characteristics of syphilis-infected pregnant women in East China and its associated factors. Methods Data of syphilis-infected pregnant women in East China from the national ‘Information System of Prevention of Mother-to-child Transmission of HIV,syphilis and HBV Management＇were analyzed in our study. We described the demographic and infection-related characteristics and non-treponemal titer. We analyzed factors associated with non-treponemal titer using logistic regression model. Results There were 9101 syphilis-infected pregnant women in East China in 2015. There were 4613（ 50. 7%） women who received antenatal care visit in their first trimester of pregnancy,while only 2805（ 30. 8%） were diagnosed during the first trimester. There were 5640（ 62. 0%） women that were unware of their route of infection. Syphilis infection status of 5954（ 65. 4%） women＇shusband/partners were unknown. High level of none-treponemal titer（ ≥1 ∶ 8） was associated with age,marriage status,education,first antenatal care visit,syphilis infection history and husband/partner infection status. Conclusion Diagnosis delay of maternal syphilis was not rare among pregnant women. The infected pregnant women were at risk of re-infection. We suggest to further reduce congenital syphilis risks by continuing optimizing prevention of mother-to-child transmission care,standardizing counselling,diagnosis,treatment and follow-up practices,and promoting testing uptake in partners.

关 键 词：梅毒 孕产妇 检测 影响因素 

分 类 号：R759.15[医药卫生—皮肤病学与性病学]