狂犬病疫苗和人狂犬病免疫球蛋白联合应用早期免疫效果分析  

Analysis of the early immune effects of rabies vaccine combined with human rabies immunogiobulin

作　　者：朱泽荣[1] 鲁莎[1] 朱政纲[1] 张曼 郑熠 胡权 Zhu Zerong;Lu Sha;Zhu Zhenggang;Zhang Man;Zheng Yi;Hu Qaan Wuhau(Centers for Disease Control and Prevention, Wuhan 430015, China;Wahaa Institute of Dermatology and Venereology, Wuhan 430032, China)

机构地区：[1]武汉市疾病预防控制中心,430015 [2]武汉市皮肤病防治研究所,430031

出　　处：《中华实验和临床病毒学杂志》2018年第3期228-232,共5页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的揭示狂犬病疫苗和人狂犬病免疫球蛋白（human rabies immunoglobulin，HRIG）联合应用早期免疫效果。方法采用快速荧光灶抑制试验（rapid fluorescent focus inhibition test，RFFIT）检测观察对象血清狂犬病病毒中和抗体（rabies virus neutralizing antibodies，RVNA），比较狂犬病Ⅲ级暴露人群联合使用狂犬病疫苗和HRIG后第0、1、7、14、45天的RVNA水平，进一步分析不同性刖、年龄组、接种方案免疫效果的差异和变化趋势。结果在免疫后的相同时间，不同性别、年龄绀、接种方案之间比较，各组血清阳转率（seroeonversion rate，SCR）差异无统计学意义，在第14天均能达到100％阳转率；前14天的RVNA效价波动曲线存在多种方式，既有逐步上升，也有快速上升和快速下降的不同现象。结论狂犬病疫苗和HRIG联合应用后，前14天的RVNA动态曲线呈现多样性，在此期间不能从RVNA水平证实全部观察对象得到有效保护。Objective To investigate the early immune effects of rabies vaccine combined with human rabies immunoglobulin （HRIG）. Methods Rapid fluorescent focus inhibition test （RFFIT） was used In lest the titers of rabies virus neutralizing antibodies （ RVNA）. The titers of RVNA of persons who had exposed to rabies at degree Ⅲ on day 0, day 1, day 7, day 14 and day 45 were compared. The dynamic curves and seroconversion rates （SCR） of RVNA in persons of different genders, age and vaccine regimens （Essen and Zagreb） groups were analyzed. Results No significant differences of SCR among different genders, age and vaccine regimens groups were observed on the same day. SCR could be 100% on dayl4 in different groups. The dynamic curves of RVNA within the first 14 days showed the models of gradual rise, rapid rise and rapid decline. Conclusions The dynamic curves of RVNA within the first 14 days varied when rabies vaccines were used in combination with HRIG, and not all subjects were proved to be protected based on the RVNA detection within this period.

关 键 词：狂犬病疫苗 人狂犬病免疫球蛋白 狂犬病病毒中和抗体 快速荧光灶抑制试验 

分 类 号：R512.99[医药卫生—内科学]