溃疡性结肠炎合并巨细胞病毒感染患者临床特点  

Clinical characteristics of ulcerative colitis with cytomegalovirus infection

作　　者：林冠霞[1] 黄伟峰 史美娜[1] 徐桂华[1] Lin Guanxia;Huang Weifeng;Shi Meina;Xu Guihua(Department of Gastroenterology, the First Hospital Affiliated to Xiamen University, 361000, China)

机构地区：[1]厦门大学附属第一医院消化内科,361000

出　　处：《中华实验和临床病毒学杂志》2018年第3期305-308,共4页Chinese Journal of Experimental and Clinical Virology

基　　金：福建省科技计划资助项目（2013D009）

摘　　要：目的探讨溃疡性结肠炎（ulcerative colitis，UC）合并巨细胞病毒（Cytomegalovirus，CMV）感染患者的临床特点及结局。方法回顾性分析厦门大学附属第一医院消化内科2013年1月至2017年10月收治的300例UC患者相关资料，其中合并CMV感染80例者为观察组，未合并CMV感染220例为对照组，比较两组疾病特征、临床特点、治疗及结局情况。结果疾病特征：观察组病程显著短于对照组（t＝18.498，P〈0.05）；观察组既往糖皮质激素、免疫抑制剂应用率均显著高于（χ^2＝31.241、10.381，P〈0.05）；观察组糖皮质激素依赖、糖皮质激素抵抗发生率均显著高于对照组（χ^2＝17.513、64.927，P〈0.05）。临床特征：观察组发热、腹痛、体质量下降发生率显著高于对照组（χ^2＝25.112、20.633、13.000，P〈0.05）；结肠镜显示溃疡率显著高于对照组（χ^2＝15.496，P〈0.05）。结局：观察组好转率55.00%，显著低于对照组的79.55%（χ^2＝17.933，P〈0.05）。结论UC合并CMV感染患者相比未感染者临床症状明显，病情更严重，溃疡率高，临床结局更差。ObjectiveTo investigate the clinical characteristics and outcomes of ulcerative colitis （UC） with cytomegalovirus （CMV） infection.MethodsThe related data of 300 patients with UC who were treated in the department of gastroenterology of the First Affiliated Hospital of Xiamen University from January 2013 to October 2017 were analyzed retrospectively. Eighty cases with CMV infection were included into the observation group while 220 cases without CMV infection were enrolled into the control group. The disease characteristics, clinical features, treatment and outcomes were compared between the two groups.ResultsFor disease characteristics, course of disease in observation group was significantly shorter than that in the control group （t=18.498, P〈0.05）. The previous application rates of glucocorticoid and immunosuppressant in the observation group were significantly higher than those in the control group （χ^2=31.241, 10.381, P〈0.05）. The incidence rates of glucocorticoid dependence and glucocorticoid resistance in the observation group were significantly higher than those in the control group （χ^2=17.513, 64.927, P〈0.05）. For clinical characteristics, the incidence rates of fever, abdominal pain and weight loss in the observation group were significantly higher than those in the control group （χ^2=25.112, 20.633, 13.000, P〈0.05）. Colonoscopy showed that the ulcer rate in observation group was significantly higher than that in the control group （χ^2=15.496, P〈0.05）. For outcomes, the improvement rate of the observation group was significantly lower than that of the control group （55.00% vs. 79.55%） （χ^2=17.933, P〈0.05）.ConclusionsThe clinical symptoms of patients with UC and CMV infection are more obvious, the disease was more serious, the ulcer rate is higher and the clinical outcomes were worse than those of uninfected patients.

关 键 词：溃疡性结肠炎 巨细胞病毒感染 临床特点 

分 类 号：R511[医药卫生—内科学] R574.62[医药卫生—临床医学]