微重力环境下MicroRNA调控成骨细胞分化研究进展  

Research Progress on MicroRNA Regulating Osteoblast Differentiation under Microgravity

作　　者：张扬 张西正[1] ZHANG Yang;ZHANG Xizheng(Institute of Medical Equipment, Academy of Military Medical Sciences, Tianjin 300161, China)

机构地区：[1]军事医学科学院卫生装备研究所

出　　处：《医用生物力学》2018年第3期285-290,共6页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(31370942,11432016)

摘　　要：MicroRNA（miRNA）是生物学过程中基因表达的重要调控分子,但miRNA在骨组织代谢过程中发挥的重要调控作用尚未完全阐明。综述现阶段miRNA在微重力环境下对成骨细胞分化的调控作用,对miRNA的调控作用分为正负两类分别进行归纳,重点介绍不同基因的作用机制,并列举在微重力环境下对骨组织代谢有重要影响的一些miRNA分子。微重力环境下miRNA对骨组织代谢性疾病具有比较重要的调控作用,其相关研究对预防及治疗失重性骨质缺失病症意义重大。MicroRNA（ miRNA） is a kind of important gene expression regulatory molecules during biological process,but its regulation mechanism in metabolic process of bone tissues has not been completely clarified. In this review,the regulation of miRNA on osteoblast differentiation in microgravity environment was discussed. The positive and negative regulation of miRNA was summarized,respectively,with focus on introducing the mechanism of different genes. Some miRNA molecules that have important effects on bone metabolism under microgravity were enumerated. MiRNA plays an important role in regulating and controlling bone metabolic diseases in microgravity environment,and its related studies are significant for the prevention and treatment of bone loss induced by weightlessness.

关 键 词：微小RNA 微重力环境 成骨细胞 骨代谢 调控机制 

分 类 号：R318.01[医药卫生—生物医学工程]