梅毒血清固定机制的研究进展  

Advances in mechanism of syphilis serofast

作　　者：李维 刘双全[1] LI Wei;LIU Shuang-quan(The First Affiliated Hospital of University of South China, Hengyang 421000, Hunan Province, China)

机构地区：[1]南华大学附属第一医院检验科,湖南衡阳421000

出　　处：《微生物学免疫学进展》2018年第3期82-85,共4页Progress In Microbiology and Immunology

基　　金：国家自然科学基金(81201331)

摘　　要：经正规驱梅治疗后,梅毒血清固定患者血清反应素滴度可长期呈低滴度不下降。血清固定的发生主要与梅毒分期、血清初始滴度、无症状神经梅毒、苍白螺旋体(Treponema palladium,TP)重复基因型分型和细胞免疫抑制等因素有关。目前梅毒血清固定的机制不明,研究提示,梅毒血清固定与机体的免疫失衡和免疫抑制有关。从调节性T细胞(regulatory T cells,Tregs)/Th17细胞平衡异常、Toll样受体表达异常、Th1/Th2型细胞因子的失衡、T细胞亚群比例失调及microRNA表达谱的改变等方面,对梅毒血清固定机制的研究进展作一综述。After standard treatment,the rapid plasma region titers of the patients suffered from syphilis with serofast can be long-term low titer. The occurrence of the serofast is mainly associated with syphilis staging,serum initial titer,asymptomatic neurosyphilis; TP repeat genotyping,cellular immunosuppression and other factors. Currently,the mechanism of serofast is still unclear. and which is believed to be related to unbalance of immune system and immuno-suppression. This article will discuss on different aspects related to serofast mechanism,including the abnormal balance of Tregs/Th17 cells,the abnormal Toll-like receptor expression,the unbalance of Th1/Th2 cytokines,the unbalance of T cell subsets and the change of microRNA expression profile.

关 键 词：梅毒 血清固定 发病机制 免疫失衡 免疫抑制 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]