纳米微管中线粒体转移在急性肺损伤修复中的作用  

Role of mitochondrial transfer in nanotubules in repair of acute lung injury

作　　者：刘笑然[1] 钱进 孙东梅[2] 黄琪锋 Liu Xiaoran;Qian Jin;Sun Dongmei;Huang Qifeng(Department of Emergency, the First Affiliated Hospital of Hainan Medical University, Haikou 570102, China)

机构地区：[1]海南医学院第一附属医院急诊科,海口570102 [2]海南医学院,海口570000

出　　处：《国际呼吸杂志》2018年第11期871-874,共4页International Journal of Respiration

基　　金：国家自然科学基金（81260010、81460006、81660011）

摘　　要：急性肺损伤是脓毒症常见的并发症，发病急，病情变化快，病死率高，目前临床上尚无有效的治疗手段，寻找一种有效的治疗方法迫在眉睫。大多数学者认为脓毒症引起急性肺损伤与线粒体大量损伤有关。近年来，一种被广泛研究的多能干细胞——间充质于细胞已被证明可以通过纳米管以依赖微管传递的方式运输线粒体来缓解和治疗脓毒症所致急性肺损伤。本文就近年来这方面的研究进展进行综述。Acute lung injury is a common complication of sepsis. It has an acute onset, rapid changes in condition, and a high mortality. Currently, there is no effective treatment method in clinical practice. Finding an effective treatment method is imminent. Most scholars believe that acute lung injury caused by sepsis is associated with massive mitochondrial damage. In recent years, a widely studied pluripotent stem cell, mesenchymal stem cells, has been shown to relieve and treat acute lung injury due to sepsis by transporting mitoehondria via nanotubes in a microtubule-dependent manner. This article reviews the research progress in this area.

关 键 词：间质干细胞 纳米微管 线粒体 脓毒症 急性肺损伤 活性氧簇 

分 类 号：R563[医药卫生—呼吸系统]