成人麻疹并急性肝损害患者血清IL-33高表达的临床意义  

Variations of serum IL-33 levels in patients with adult measles complicated acute liver damage and its clinical significance

作　　者：刘春华[1] 王伟红[1] 崔霞[1] 刘晶晶[1] 李庆彦[1] 王思奎[1] 刘菲 LIU Chun-Hua;WANG Wei-Hong;CUI Xia;LIU Jing-Jing;LI Qing-Yan;WANG Si-Kui;LIU Fei(Department of Infections ,Liaocheng People＇s Hospital, Liaocheng 252000, Chin)

机构地区：[1]聊城市人民医院感染科,聊城252000 [2]中南大学湘雅医学院感染科,长沙410008

出　　处：《中国免疫学杂志》2018年第6期902-905,共4页Chinese Journal of Immunology

基　　金：湖南省自然科学基金项目(12JJ4078)

摘　　要：目的:探讨麻疹并急性肝损害患者血清IL-33的水平变化及临床意义。方法:选取成人麻疹并肝损害60例为研究对象,无肝损害28例为对照,同时纳入查体中心20例健康人为健康对照。采用酶联免疫吸附测定法(ELISA法)测定血清IL-33的水平,于第0、7、14天动态观察肝损害组血清IL-33变化,并分析血清IL-33水平与临床生化及炎症指标的相关性。将60例肝损害患者按照随机数字法分为保肝组和无保肝组,各30例,对比第7和14天两组患者间血清IL-33变化。结果:麻疹并肝损害、麻疹无肝损害患者血清IL-33水平分别为(205.20±25.74)pg/ml、(168.70±18.14)pg/ml,均显著高于健康对照[(132.17±12.41)pg/ml,P<0.05],以肝损害组显著;第7天,无保肝组血清IL-33表达显著高于保肝组。第14天,保肝和无保肝两组间血清IL-33表达差异无统计学意义(P>0.05);随时间延长,肝损害组患者血清IL-33呈下降趋势,于治疗第14天与健康对照组间差异无统计学意义(P>0.05);血清IL-33水平与肝损害的程度一致。相关分析提示IL-33与ALT、GGT、IL-6呈正相关(r=0.392 1、0.503 9、0.724 9,P<0.001)。结论:血清IL-33在麻疹肝损害中呈高水平表达,IL-33可能参与麻疹病毒诱发的急性肝损害的发生、发展及转归。Objective：To study changes and clinical significance of serum interleukin-33（IL-33） of patients with adult measles complicated acute liver damage.Methods：Totally,88 adult measles patients were selected and divided into acute liver damage group（n=60） and no liver damage group（n=28）.At the same time,20 healthy adults were selected as healthy controls.Serum IL-33 levels were measured by enzyme linked immunosorbent assays.Venous blood samples of IL-33 were drawn on the day of admission and were repeated at 7 and 14 days later.The correlation of IL-33 and biochemical indicators were analyzed.60 patients with liver damage were divided into protecting liver and without protecting liver group in accordance with the method of random numbers.The level of serum IL-33 was compared at 7 and 14 days between the two groups of patients.Results：Patients with adult measles complicated acute liver damage and no liver damage had elevated serum IL-33 levels than that in the controls [（205.20 ± 25.74） pg/ml,（168.70 ±18.14） pg/ml,vs（132.17±12.41） pg/ml,P〈0.05 for all],especially in acute liver damage group.The expression of serum IL-33 in no protecting liver group was significantly higher than protecting liver group at 7 th day.IL-33 was no significant difference in patients between protecting liver and without protecting liver groups at 14 th day（P〉0.05）.The level of IL-33 was a significant decrease in the treatment and there was no significant difference between healthy controls at 14 th day（P〉0.05）.The level of IL-33 and liver damage were consistent.Serum IL-33 levels in patients with liver damage showed positive correlation with levels of ALT,GGT and IL-6（r =0.392 1,0.503 9,0.724 9,P〈0.001）.Conclusion：IL-33 may have proinflammatory effects in the phase of adult measles complicated acute liver damage and its serum level reflects the severity of liver inflammation.

关 键 词：麻疹 肝损害 血清IL-33 

分 类 号：R511.1[医药卫生—内科学]