血管生成素样蛋白3在肾病综合征中的研究进展  

Research progress of angiopoietin-like-3 in nephrotic syndrome

作　　者：李鑫[1] 吕慧妍[1] 郝丽荣[1] LI Xin;LU Huiyan;HAO Lirong(Department of Nephropathy, First Affiliated Hospital, Harbin Medical University, Harbin 150070, China)

机构地区：[1]哈尔滨医科大学附属第一医院肾内科,哈尔滨150070

出　　处：《临床与病理杂志》2018年第5期1104-1108,共5页Journal of Clinical and Pathological Research

摘　　要：血管生成素样蛋白3(angiopoietin-like-3,ANGPTL3)是一种分泌蛋白,是血管生成素样蛋白家族的成员。ANGPTL3主要表达于肝,肾仅有少量表达。肾病综合征(nephrotic syndrome,NS)是以大量蛋白尿(>3.5 g/d)、低白蛋白血症(<30 g/L)、水肿及高脂血症为特点的临床综合征,可表现为各种病理类型。近期研究发现肾ANGPTL3表达异常与NS的常见病变足细胞损伤和蛋白尿相关,并参与NS高脂血症的调节。Angiopoietin-like-3（ANGPTL3） is a secreted protein with a characteristic angiopoietin structure and it belongs to ANGPTL protein family. ANGPTL3 is mainly expressed in hepatocytes and only weakly expressed in normal kidney cell. Nephrotic syndrome（NS） is a clinical syndrome characterized by massive proteinuria（〉3.5 g/d）, hypoalbuminemia（〈30 g/L）, edema and hyperlipidemia. NS can involve various pathological types of kidney disease. Recent studies have found that the abnormal expression of ANGPTL3 in kidney is related to podocyte injury and proteinuria in NS, and is involved in the regulation of hyperlipidemia in NS.

关 键 词：血管生成素样蛋白3 肾病综合征 足细胞 高脂血症 

分 类 号：R692[医药卫生—泌尿科学]