血浆血红素加氧酶1和基质金属蛋白酶9与冠心病的相关性分析  

Correlation of plasma heme oxygenase-1 and matrix metalloproteinase-9 with coronary artery disease

作　　者：刘晶晶[1] 井立省[1] 王军[1] LIU Jingjing;JING Lisheng;WANG Jun(Department of Cardiology, Mentougou District Hospital of Bejing, Beijing, 102300, China)

机构地区：[1]北京市门头沟区医院心内科,北京102300

出　　处：《第三军医大学学报》2018年第13期1247-1250,共4页Journal of Third Military Medical University

摘　　要：目的探讨血浆血红素加氧酶1(heme oxygenase-1 HO-1)和血浆基质金属蛋白酶9(matrix metalloproteinase-9,MMP-9)与冠心病的相关性。方法选择2011年3月至2014年12月在北京市门头沟区医院心内科疑似冠心病的住院患者292例,其中男性167例,女性125例;年龄34~90(64±12)岁。根据冠脉造影(coronary angiography,CAG)结果分为对照组(143例)和冠心病组(149例),冠心病组根据病变支数又分为单支病变(38例)、双支病变(46例)、多支病变(65例),测量患者HO-1及MMP-9水平,计算冠心病组Gensini积分;同时收集病史、尿酸、血脂、高敏C反应蛋白、糖化血红蛋白等指标,评价HO-1、MMP-9与冠心病的相关性。结果 (1)冠心病组MMP-9及Gensini积分明显高于对照组(P<0.05),HO-1水平明显低于对照组(P<0.05);(2)MMP-9及Gensini积分随着病变血管数增加而升高(P<0.05),HO-I水平则降低(P<0.05);(3)HO-1与Gensini积分呈负相关(r=-0.952,P<0.01),MMP-9与Gensini积分呈正相关(r=0.881,P<0.01),HO-1与MMP-9呈负相关(r=-0.818,P<0.01)。结论血浆中HO-1和MMP-9水平与冠心病有关。metalloproteinase-9 Objective To investigate the correlation of heme oxygenase-1 （HO-1） and matrix （MMP-9） with coronary artery disease （CAD）. Methods A prospective cohort study was carried out on 292 inpatients （167 males and 125 females, at a mean age of 64 ± 12 years, ranging from 34 to 90 years） with suspected CAD admitted in our department during March 2011 and December 2014. According to the results of coronary angiography （ CAG）, the patients were divided into control group （ n = 143 ） and CAD group （ n = 149）. According to the number of vessels involved, the patients of CAD group was further divided into one-vessel subgroup （n = 38）, two-vessel subgroup （n = 46）, and multi-vessel subgroup （ n = 65 ）. The plasma levels of HO-1 and MMP-9 were measured in all the patients, their medical history was collected, and the results of uric acid, blood lipids, high sensitivity C-reactive protein （Hs-CRP）, glycosylated hemoglobin were recorded. Gensini＇ s score was calculated in the CAD group. The correlations of HO-1 and MMP-9 with CAD were analyzed. Results （1） The MPV level and Gensini＇ s score in the CAD group were obviously higher than those in the control group （ P 〈 0.05 ）, while the level of HO-1 was significantly lower （P 〈 0.05 ）. （2） With more vessels involved, the MMP-9 level and Gensini＇ s score were significantly increased （ P 〈 0.05 ）, while the HO-1 level was notably decreased （ P 〈 0.05 ）. （3） The level of HO-1 was negatively correlated with Gensini＇ s score （ r = - 0. 952, P 〈 0.01 ）, while that of MMP-9 was positively （r =-0. 881, P 〈 0.01 ）. Furthermore, the levels of the 2 indicators were negatively correlated （r = -0. 818, P 〈0.01 ）. Conclusion Plasma HO-1 and MMP-9 levels are associated with CAD.

关 键 词：血红素加酶1 基质金属蛋白酶9 冠心病 

分 类 号：R345[医药卫生—基础医学] R446.112