布瓦西坦的不对称合成研究进展  

Progress in asymmetric synthesis of brivaracetam

作　　者：周超[1,2] 曾景 李建其 倪峰[1,2] ZHOU Chao;ZENG Jing;LI Jian-qi;NI Feng(Novel Technology Center of Pharmaceutical Chemistry, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 201203, China;Shanghai Engineering Research Center of Pharmaceutical Process, Shanghai 201203, China)

机构地区：[1]中国医药工业研究总院上海医药工业研究院化学制药新技术中心,上海201203 [2]上海药物合成工艺过程工程技术研究中心,上海201203

出　　处：《中国新药杂志》2018年第12期1372-1376,共5页Chinese Journal of New Drugs

摘　　要：布瓦西坦作为第3代抗癫痫药,拥有广阔的市场前景。本文对布瓦西坦的不对称合成路线进行调研、分析,最终确定路线4为优势路线,原料易得、收率高,适合工业化生产。Brivaracetam has a vast market potential as the third generation antiepileptic drug. We investigated and reviewed the existing asymmetric synthetic routes of brivaracetam. Route 4 is more suitable for industrialization due to its low starting materials cost and high total yield.

关 键 词：布瓦西坦 不对称合成 工业化 合成路线图解 

分 类 号：R971.6[医药卫生—药品]