非布司他对痛风患者尿α1-MG β2-MG MCP-1的观察研究  

作　　者：严婷婷 叶俏 莫娟芬 

机构地区：[1]浙江省嘉兴市第二医院,314000

出　　处：《浙江临床医学》2018年第7期1222-1224,共3页Zhejiang Clinical Medical Journal

基　　金：浙江省嘉兴市科技计划项目（2016AY23051）

摘　　要：目的观察非布司他与别嘌呤醇对痛风患者尿α1微球蛋白（α1-MG）、尿β2微球蛋白（β2-MG）、尿单核细胞趋化蛋白-1（MCP-1）的变化，评估其对肾小管功能的影响及尿MCP-1在早期痛风性肾脏病中的意义方法收集符合标准的样本61例分为三组，非布司它组（非布司他片40mg／d）、别嘌呤醇组（别嘌呤醇片0．3g／d）及对照组。比较初始及治疗后第4周、24周血常规、肝功能、肾功能、尿α1-MG、尿β2-MG、尿MCP-1等指标。结果非布司他组治疗24周后尿α1-MG、尿β2-MG、尿MCP-1水平比治疗前明显下降，与别嘌呤醇组及对照组比较差异均有统计学意义，治疗前后尿液中MCP-1含量与尿α1-MG、β2-MG水平均呈正相关。结论非布司他治疗痛风过程中患者尿液中α1-MG、β2-MG指标均较治疗前下降，提示损伤的肾小管功能好转。尿液MCP-1与尿液α1-MG、β2-MG水平密切相关，尿液MCP-1可能成为痛风患者肾小管功能评估的有效指标。Objective To observe the changes of urinary α1-Microglobulin （ α1-MG ） , urinary β2-microglobulm （ β2-MG ） , and urinary monocyte chemotactic protein-1 （MOP-1） , to evaluate the effect of febuxostat and allopurinol on renal tubule function in patients with gout and the significance of urinary MCP-1 in early gout. Methods The 61 samples that met the standard were divided into three groups, namely febuxostat group： treatment with febuxostat 40mg/d, allopurinol group： treatment with allopurinol 0.3 g/d and the control group. The changes of blood routine, liver function, renal function, urine α1 MG, urine β2-MG and urine MCP-1 were compared. Results The levels of urine α1- MG, urine β2-MG and urine MCP 1 were significantly lower than that in the 24 weeks after the treatment of the febuxostat group, and there was a statistically significant difference between the aUopuriuol group and the control group. The content of MCP-1 in urine before and after treatment was positively correlated with the level of urine α1-MG and β2 MG. Conclusion During the treatment with febuxostat, the patients＇ urine α1-MG and β2-MG are lower than before treatment, suggests that the damaged renal tubule function is improved. The urine MCP-1 is closely related to urine α1- MG and β2-MG level, and the urine MCP-1 may be an effective indicator for the evaluation of renal tubule function in gout patients.

关 键 词：痛风 非布司他 肾小管功能 尿Α1-微球蛋白 尿Β2-微球蛋白 单核细胞趋化蛋白-1 

分 类 号：R692[医药卫生—泌尿科学]