2015年河北省麻疹疫苗株感染病例分析  

Infection Cases after Measles Containing Vaccine Immunization in Hebei province 2015

作　　者：杜慧[1] 王伟[1] 张敬坡[2] 郭玉[1] 刘岩[1] 张振国[1] DU Hui;WANG Wei;ZHANG Jingpo;GUO YU;LIU Yan;ZHANG Zhenguo(Center for Disease Prevention and Control, Shifiazhuang 050021, Hebei Province, China;Third Hospital of Shijiazhuang City, Shijiazhuang 050021, Hebei Province, China.)

机构地区：[1]河北省疾病预防控制中心,石家庄050021 [2]石家庄市第三医院,石家庄050021

出　　处：《预防医学情报杂志》2018年第7期940-943,共4页Journal of Preventive Medicine Information

摘　　要：目的分析2015年河北省接种含麻疹成分疫苗(Measles Containing Vaccine,MCV)后感染疫苗株的麻疹病例感染特点。方法采用病例调查、实验室检测的方法对疫苗株感染的麻疹病例进行分析。结果河北省确诊3例MCV相关麻疹病例,病例均为首剂接种,临床表现轻,与疫苗的接种间隔均在7~8 d之间,发病及疫苗的使用批次无明显聚集性,未发现二代病例,麻疹血清学及核酸检测均为阳性,基因型别鉴定均为A基因型。结论对有免疫接种史的麻疹病例要密切追踪,并与实验室检测方法相结合,从而鉴别其感染类型。Objective To analyze the characteristics of vaccine-associated measles cases after the immunization of measles containing vaccine（ MCV） in Hebei province,2015. Methods Cases investigation and laboratory detection were used to identify the vaccine-associated measles cases. Results Three measles containing vaccine（ MCV） associated measles cases were laboratory confirmed in Hebei province. All the cases were received the first dose of MCV injection. The clinical manifestations were mild. The vaccination interval was between 7 and 8 days. There was no obvious aggregation in the onset of illness and vaccine use. In our investigation,no secondary cases occurred. Measles serology and nucleic acid detection were positive. All the measles isolated were provided to be A genotype. Conclusion Measles cases with a history of immunization of MCV should be paid a close attention. The gene of virus identification is the only way to determine and identify the cause.

关 键 词：麻疹 疫苗相关麻疹病例 含麻疹成分疫苗 基因型 

分 类 号：R373.1[医药卫生—病原生物学]