消斑饮加减治疗面部激素依赖性皮炎的疗效及对Th1/Th2细胞水平的影响  

Efficacy of Addition and Subtracton of Xiaobanyin on Facial Hormone-Dependent Dermatitis and Effect on Level of Th1/Th2 Cell

作　　者：周君武 薛素琴[2] ZHOU Jun-wu;XUE Su-qin(The First People＇s Hospital of Shuangliu District, Chengdu 610200, China;Guangdong Hospital of Traditional Chinese Medicine, Guangzhou 510405, China)

机构地区：[1]成都市双流区第一人民医院,成都610200 [2]广东省中医院,广州510405

出　　处：《中国实验方剂学杂志》2018年第14期176-181,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广东省中医药局中医药科研课题(20161119)

摘　　要：目的：探讨消斑饮加减治疗面部激素依赖性皮炎（HDD）的疗效及对辅助性T细胞免疫炎症和皮肤屏障功能的影响。方法：将119例HDD患者采用分层区组,随机按数字表法分为对照组59例和观察组60例。对照组口服氯雷他定片,10 mg/次,1次/d;和硫酸羟氯喹片,0.2 g/次,2次/d。观察组在对照组治疗的基础上加服消斑饮加减,1剂/d。两组疗程均为连续治疗8周。记录治疗前后主观症状和客观皮损症状评分;进行治疗前后皮肤屏障功能检测;检测治疗前后干扰素-γ（IFN-γ）,白细胞介素-2（IL-2）,IL-4,IL-6,IL-10,IL-1,IL-13和肿瘤坏死因子-α（TNF-α）水平;进行治疗前后皮肤病生活质量指数（DLQI）评价。结果：观察组临床疗效总有效率为93.33%,高于对照组的79.66%（χ^2=4.778,P〈0.05）;观察组患者症状积分低于对照组（P〈0.01）;观察组患者的角质层含水量和皮脂含量均高于对照组,经皮水分丢失少于对照组（P〈0.01）;观察组血清IFN-γ,IL-2水平均高于对照组,IL-4,IL-6,IL-10水平均低于对照组（P〈0.01）;观察组血清IL-1,IL-13和TNF-α水平均低于对照组（P〈0.01）;观察组患者的DLQI量表各维度评分及总分均低于对照组（P〈0.01）。结论：消斑饮加减在西医治疗的基础上,可明显缓解HDD症状,提高临床疗效和生活质量,并具有调节Th1/Th2细胞因子,减轻炎症损伤,促进皮肤屏障功能修复的作用。Objective： To discuss the efficacy of addition and subtracton of Xiaobanyin on facial hormone-dependent dermatitis（ HDD） and its effect on helper T cells immune inflammation and skin barrier function. Method： One hundred and nineteen patients with HDD were randomly divided into control group 59 cases and observation group 60 cases by random number table and hierarchical block designs. Patients in control group were given loratadine tablets,10 mg/time,1 time/day. And hydroxychloroquine sulfate tablets,0. 2 g/time,2 times/days. In addition to the therapy of control group,patients in observation group were also given addition and subtracton of Xiaobanyin,1 dose/day. A course of treatment was 8 weeks. Before and after treatment,scores of subjective symptoms and objective skin injury were recorded. Skin barrier function, interferon-γ（ IFN-γ）,interleukin-2（ IL-2）,IL-4,IL-6,IL-10,IL-1,IL-13 and tumor necrosis factor-α（ TNF-α） were detected. And dermatology life quality index（ DLQI） was evaluated. Result： The total effect rate in observation group was93. 33%,which was higher than 79. 66% in control group（ χ^2= 4. 778,P〈0. 05）. Score of symptom in observation group was lower than that in control group（ P〈0. 01）. Water content of corneum and sebum in observation group were higher than those in control group,while transepidermal water loss was less than that in control group（ P〈0. 01）. And levels of IFN-γ and IL-2 were higher than those in control group,whereas levels of IL-4,IL-6,IL-10,IL-1,IL-13,TNF-α scores of DLQI and the total score were lower than those in control group（ P〈0. 01）. Conclusion： In addition to the therapy of western medicine treatment,addition and subtracton of Xiaobanyin can relieve the symptom of HDD and inflammatory injury,improve the quality of life and the clinical effect,regulate levels of Th1/Th2 cytokines and promote the recovery of skin barrier function.

关 键 词：激素依赖性皮炎 消斑饮 辅助性T细胞 皮肤屏障功能 

分 类 号：R289[医药卫生—方剂学] R275[医药卫生—中药学]