颗粒蛋白前体与胰岛素抵抗及2型糖尿病的关系  

Relationship between PGRN,insulin resistance and type 2 diabetes

作　　者：程海燕[1] 卜瑞芳[1] 王霞娟[1] 吴文君[1] CHENG Haiyan;BU Ruifang;WANG Xiajuan;et al.(Department of Endocrinology and Metabolism, Wuxi People＇s Hospital, Nanjing Medical University, Wuxi 214000, China)

机构地区：[1]南京医科大学附属无锡市人民医院内分泌代谢科,214000

出　　处：《中国糖尿病杂志》2018年第6期520-522,共3页Chinese Journal of Diabetes

基　　金：国家自然科学基金(81500630)

摘　　要：IR是T2DM及其微血管并发症的重要病理生理基础,近年研究认为,慢性炎症是引起IR的关键因素。颗粒蛋白前体(PGRN)作为一种新型的炎症细胞因子,可通过调控慢性炎症反应引起IR、组织局部炎症浸润来参与糖尿病及其微血管并发症的发生发展,还可作为一种细胞生长因子引起血管化参与DR的发生发展。对上述领域的探索有助于进一步明确PGRN与IR、T2DM及微血管并发症之间的关系,以期为后者探寻新的治疗靶点。Insulin resistance（IR）is an important pathophysiological basis of type 2 diabetes（T2 DM）and its microvascular complications.Recent researches have found that chronic inflammation is a critical factor for IR.As a new inflammatory cytokine,progranulin（PGRN）can be involved in the occurrence and development of diabetes and its microvascular complications through regulation of IR and local inflammatory infiltration.It may also acts as a cell growth factor inducing vascularization in the occurrence and development of diabetic retinopathy（DR）.The exploration of the above areas will help to further clarify the relationship between PGRN and IR,T2 DM and its microvascular complications,and to explore new therapeutic targets in the future.

关 键 词：颗粒蛋白前体 胰岛素抵抗 糖尿病 2型 

分 类 号：R587.1[医药卫生—内分泌]