丁螺环酮合并认知行为疗法对救援官兵惊恐障碍的疗效分析  

Efficacy of buspirone combined with cognitive therapy on panic disorder of rescue soldiers

作　　者：周喻[1] 贺智[1] ZHOU Yu;HE Zhi.(logistics university of People＇s Armed Police Force ,Tianjin 300162)

机构地区：[1]中国人民武装警察部队后勤学院,天津300162

出　　处：《中国急救复苏与灾害医学杂志》2018年第6期571-573,共3页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：天津市社科基金（TJJX13）

摘　　要：目的分析丁螺环酮合并行为认知疗法对救援官兵惊恐障碍的治疗效果，并评价其副作用。方法随机选取2015年8月-2016年8月武警天津某部队医院45例某部队医院随机选取45例患有惊恐障碍的救援官兵，给予4周，每周一次的认知行为疗法，同时口服丁螺环酮，于治疗前和治疗4周后运用汉密尔顿焦虑量表（hamilton anxiety scale, HAMA）评估患者的焦虑症状，治疗后运用副反应量表（treatment emergent symptomscale, TESS）评价药物副作用，对搜集的数据进行统计分析。结果①经过4周的治疗，患有惊恐障碍的救援官兵HAMA总分和因子分显著低于治疗前；②4周的联合治疗，患有惊恐障碍的救援官兵痊愈率为37．78％、显著进步率28．89％、进步率20．00％、无效率为13．33％；③丁螺环酮不良反应的发生率为17．78％，主要表现为：头痛、口干和食欲减退。结论丁螺环酮合并行为认知疗法对患有惊恐障碍的救援官兵疗效明显，副作用轻微。Objective To analyze the effects of buspirone, receptor of 5-hydroxytryptamine, combined with cognitive therapy. Methods 45 rescue soldiers with panic disorder, 42 males and 3 females, aged（35.43±5.76） （30-45）, all of Han nationality, were randomly selected and given the treatment of buspirone combined with cognitive therapy. Hamilton Anxiety Scale （HAMA） was used to evaluate their symptoms before treatment and 4 weeks after treatment. Treatment emergent symptom scale （TESS） was used to evaluate the adverse reaction of buspirone. Results ①The HAMA total score after treatment was （11.44±4.9）4, significantly lower than that be＇fore treatment [（31.88±7.58）, P〈 0.001]. The somatic anxiety score after treatment was （4.03 ± 1.29）, significantly lower than that before treatment [（13.34±3.32）, P〈0.004].The mental anxiety score after treatment was （7.41±2.31）, significantly lower than that before treatment [（18.54±4.03）, P〈0.023]. ②After 4 weeks＇ treatment, the cure rate, remarkable progress rate, progress rate, and no efficiency rate of the rescue soldiers with panic disorder undergoing treatment were 37.78%, 28.89%, 20.00%, and 13.33% respectively. ③The adverse reactions incidence rate of buspirone was 17.78%. The mainly adverse reactions were headache, dry mouth and loss of appetite. Conclusion Buspirone combined with cognitive therapy has remarkable effects in the treatment of panic disorder among the rescue soldiers with little side effect.

关 键 词：惊恐障碍 丁螺环酮 认知行为疗法 救援官兵 

分 类 号：R129[医药卫生—环境卫生学]