外周血hs-CPR、CD11b阳性细胞和CD64阳性细胞对早产儿早期感染的诊断价值  

Diagnostic value of peripheral hs-CPR,CD11b-positive cells and CD64-positive cells in early infections among premature children

作　　者：李晨[1] 姬静璐[1] 王玉[1] 魏继红[1] 李朝英[1] 李少华[1] 安娜[1] LIChen;JI Jinglu;WANG Yu;WEI Jihong;LI Zhaoying;LI Shaohua;and AN Na(Department of Pediatrics, the Affiliated Hospital of Hebei University, Hebei Baoding 071000, China)

机构地区：[1]河北大学附属医院儿科,保定071000

出　　处：《武警医学》2018年第5期480-482,486,共4页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的比较流式细胞仪分析指标与传统感染指标在早产儿感染早期诊断中的应用价值。方法选择我院住院早产儿72例,依据诊断结果分为感染组34例,非感染组38例。采用流式细胞仪检测CD11b和CD64,免疫比浊分析法测定hs-CPR,光化学染色检测血小板,全自动五分类血细胞分析仪检测白细胞(以后用WBC代表),统计分析。结果感染组CD11b、Hs-CRP和CD64显著高于非感染组(t=8.88,P<0.01;t=22.62,P<0.01;t=24.79,P<0.01);CD11b灵敏度为0.90,特异性为0.98,阳性预测值为0.98,阴性预测值为0.98。结论外周血CD11b阳性细胞对早产儿早期感染的诊断价值高于hs-CPR和CD64阳性细胞。Objective To compare the applicability of flow cytometry analysis indexes and the traditional indexes in early diagnosis of infected preterm children. Methods Seventy-two cases of preterm children treated in our hospital were divided into the infected group and normal group based on the diagnosis. CD11 b and CD64 of these patients were detected with flow cytometry,hs-CPR with immunoassays,platelet with photochemical staining turbidimetric assay,WBC analyzed with a full-automatic hematology analyzer.Statistical analysis was conducted. Results There was no significant difference in general information between the two groups of patients（ P〈0. 05）. CD11 b,Hs-CRP and CD64 in the infected group were significantly higher than those in the normal group（ t =8. 88,P〈0. 01; t = 22. 62,P〈0. 01; t = 24. 79,P〈0. 01）. The sensitivity of CD11 b was 0. 90,the specificity was 0. 90,the positive predictive value was 0. 98 and negative predictive value was 0. 98. Conclusions The diagnostic value of CD11 b-positive cells is higher than that of Hs-CPR and CD64-positive cells for early infections among premature children.

关 键 词：流式细胞仪 HS-CRP CD11B CD64 早产儿感染 

分 类 号：R722[医药卫生—儿科]