思瑞康治疗甲基苯丙胺所致精神障碍及精神分裂症疗效对比的回顾性观察  

The comparative observation of the clinical effectiveness of the methamphetamine-induced mental disorders and schizophrenia with seroquel

作　　者：高尚[1] 王汉文 刘琳[1] 田凤鸣[1] 钟明 GAO Shang;WANG Hanwen;LIU Lin;TIAN Fengming;ZHONG Ming(The An Kang Hospital of Heilongfiang Province Public Security Department, Haerbin, 150078, China)

机构地区：[1]黑龙江省公安厅安康医院,哈尔滨150078

出　　处：《中国药物依赖性杂志》2018年第3期225-228,共4页Chinese Journal of Drug Dependence

摘　　要：目的:对比观察思瑞康治疗甲基苯丙胺所致精神障碍及精神分裂症的临床疗效。方法:采用回顾性研究方法,收集应用思瑞康治疗甲基苯丙胺所致精神障碍及精神分裂症的患者各40例临床资料,其中诊断为精神分裂症的患者既往未使用过苯丙胺类物质及其他精神活性物质,治疗时间均为四周,用药前后采用简明精神病评定量表(BPRS)评价效果,采用药物副反应量表(TESS)评定药物副反应。结果:甲基苯丙胺所致精神障碍组总有效率95.00%,精神分裂症组总有效率85.00%,精神分裂症患者服用此药物的副反应要明显高于甲基苯丙胺所致精神障碍患者。结论:思瑞康治疗甲基苯丙胺致精神障碍者及精神分裂症疗效相当,但两者在副反应等方面存在显著差异。Objective： To observe the clinical effectiveness of the methamphetamine-induced mental disorders and schizophrenia with seroquel.Methods： A retrospective analysis were used,collecting each 40 clinical data of methamphetamine-induced mental disorders and schizophrenia with seroquel treated.Patients diagnosed with schizophrenia have not previously used methamphetamine and other psychoactive substances. The treatment time was four weeks. Using Brief Psychiatric Rating Scale（ BPRS） to assess the clinical effectiveness in the before and after medication,and using TESS to assess drug side effects.Results： The effective rate of the methamphetamine-induced mental disorders was 95. 00% and that of the schizophrenia group was 85. 00%. The side effect of taking the drug in schizophrenia was significantly higher than that of methamphetamine.Conclusion： The treatment effect of seroquel in methamphetamine-induced mental disorders and schizophrenia showed equivalent, however, there were significant differences in the amount of medicine,treatment,and side effects.

关 键 词：思瑞康 甲基苯丙胺 精神分裂症 疗效对比 

分 类 号：R971.41[医药卫生—药品]