不同剂量比索洛尔对充血性心力衰竭患者心率的影响  

Effect of different doses of bisoprolol on heart rate of patients with congestive heart failure

作　　者：李玥[1] 尚伟 徐中林[1] Li Yue;Shang Wei;Xu Zhonglin(Department of Cardiology,The Ninth People′s Hospital of Chongqing, Chongqing 400700, Chin)

机构地区：[1]重庆市第九人民医院心内科,重庆400700

出　　处：《保健医学研究与实践》2018年第3期38-41,54,共5页Health Medicine Research and Practice

基　　金：重庆市卫生计生委科研项目(20131047)

摘　　要：目的探讨不同剂量比索洛尔对充血性心力衰竭(CHF)患者心率的影响。方法选取2015年4月-2016年6月在重庆市某医院就诊的173例CHF患者为研究对象。采用随机数字表法将患者分为对照组(n=42)、低剂量组(n=45)、中剂量组(n=42)和高剂量组(n=44)。对照组患者应用利尿剂+血管紧张素转换酶抑制剂(ACEI)+血管扩张剂+地高辛进行治疗。低、中、高剂量组患者在对照组治疗基础上加用比索洛尔进行治疗。比较治疗前及治疗6个月时,4组患者静息偶测心率、最快心率、最慢心率、平均心率、日间平均心率(8:00-20:00)、夜间平均心率(20:00-次日8:00);比较治疗6个月时,4组患者P-R间期、QRS时限及QT间期。结果治疗后,对照组患者和低剂量组患者的静息偶测心率、最慢心率、平均心率、最快心率、日间平均心率比较,差异均无统计学意义(P>0.05)。中、高剂量组患者静息偶测心率、最慢心率、平均心率、最快心率、日间平均心率低于对照组,差异均有统计学意义(P<0.05)。中、高剂量组患者静息偶测心率、平均心率、最快心率、日间平均心率低于低剂量组,差异均有统计学意义(P<0.05)。4组患者夜间平均心率比较,差异无统计学意义(P>0.05)。中、高剂量组患者静息偶测心率、最慢心率、平均心率、最快心率、日间平均心率比较,差异均无统计学意义(P>0.05)。4组患者P-R间期、QRS时限及QT间期比较,差异无统计学意义(P>0.05)。结论应用中、高剂量比索洛尔治疗CHF的临床效果优于低剂量,且患者均未发生房室传导阻滞,证实中、高剂量比索洛尔治疗CHF是安全有效的。Objective To assess the effect of different doses of bisoprolol on the heart rate of patients diagnosed with congestive heart failure（CHF）.Methods A total of 173 patients with CHF treated at a Chongqing hospital between April 2015 and June 2016 were included in this study.Using a random number table,these patients were divided into the control group（n=42）,low-dose group（n=45）,medium-dose group（n=42）,and high-dose group（n=44）.Patients in the control group received routine treatment with diuretic＋angiotensin-converting enzyme inhibitor（ACEI）＋vasodilator＋digoxin;while those in the low-,medium-,and highdose groups received routine treatment plus bisoprolol.The resting causal heart rate,maximal heart rate,minimal heart rate,mean heart rate,daytime mean heart rate（8：00-20：00）,and nighttime mean heart rate（20：00-8：00 of the following day）were measured and compared before treatment and at 6 months after treatment initiation.Besides,the P-R interval,QRS duration,and QT interval were also compared at 6 months.Results At 6 months,the resting causal heart rate,maximal heart rate,minimal heart rate,mean heart rate,and daytime mean heart rate were comparable between the control group and the low-dose group（P〉0.05）.In the medium-and high-dose groups,the resting causal heart rate,maximal heart rate,minimal heart rate,mean heart rate,and daytime mean heart rate were significantly lower than those in the control group（P〈0.05）,and the resting causal heart rate,maximal heart rate,mean heart rate,and daytime mean heart rate were significantly lower than those in the low-dose group（P〈0.05）.The nighttime mean heart rate was similar among the 4 groups（P〉0.05）.The resting causal heart rate,maximal heart rate,minimal heart rate,mean heart rate,and daytime mean heart rate were comparable between the medium-and high-dose groups（P〉0.05）.No significant differences were noted in the P-R interval,QRS duration,and QT interval among the 4 groups（P〉0.05）.Conclusion I

关 键 词：比索洛尔 充血性心力衰竭 心率 

分 类 号：R541.7[医药卫生—心血管疾病]