基于前馈控制理念的干预措施在伏立康唑治疗黏膜皮肤念珠菌病中的效果观察  

Effect observation based on the concept of feedforward control interventions for the treatment of mucocutaneous candidiasis in voriconazole

作　　者：冯佩璐 江雪[1] 钟颖[2] 李饶[3] FENG Peilu;JIANG Xue;ZHONG Ying;LI Rao(, Department of Infectious Diseases, West China Hospital, Sichuan University, Chengdu 610041, China;Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China;Department of Endocrinology, West China Hospital, Sichuan University, Chengdu 610041, China)

机构地区：[1]四川大学华西医院感染科,四川成都610041 [2]四川大学华西医院皮肤科,四川成都610041 [3]四川大学华西医院内分泌科,四川成都610041

出　　处：《西部医学》2018年第7期1015-1018,1022,共5页Medical Journal of West China

基　　金：四川省科技计划项目(2013SZ0005)

摘　　要：目的观察前馈控制理念的干预措施在伏立康唑治疗黏膜皮肤念珠菌病中的临床效果。方法选取2015年4月~2017年5月在我院皮肤科诊断为黏膜皮肤念珠菌病的患者86例,根据数字表法随机分为观察组和对照组各43例。所有患者均采用伏立康唑治疗,其中对照组采用常规护理,观察组在对照组的基础上,采取前馈控制理念下的综合护理措施。对两组患者的临床疗效、生活质量水平及护理满意度进行比较分析。结果停药时,观察组患者临床治疗有效率为83.72%,对照组为69.77%;停药两周后,观察组患者的临床治疗有效率为90.70%,对照组为74.41%,两组差异有统计学意义(P<0.05)。两组患者真菌学检查显示,停药时,观察组的真菌清除率为86.05%,对照组为76.74%,组间差异有统计学意义(P<0.05);停药两周后,两组真菌清除率均提高,但组间差异无统计学意义(P>0.05)。而生活质量和护理满意度比较,观察组的生活质量水平和护理满意度均高于对照组(P<0.05)。结论基于前馈控制理念的干预措施在伏立康唑治疗黏膜皮肤念珠菌病中,对保证治疗效果和提高患者生活质量具有重要意义,值得临床推广应用。Objective To explore the concept of feedforward control interventions in the voriconazole treatment clinical curative effect observation of the effect of mucosal candidiasis of skin.Methods 86 patients of mucocutaneous candidiasis diagnosed in Department of dermatology in our hospital from April 2015 to May 2017 were randomly divided into the experimental group and the control group,with 43 cases in each group.All patients were treated with voriconazole treatment.The control group received conventional nursing.The experimental group on the basis of the control group,and take the feedforward control under the concept of effective comprehensive nursing measures.The clinical efficacy,quality of life and nursing satisfaction of the two groups were compared and analyzed.Results The time of drug withdrawal,the clinical curative effect of the patients in experimental group and control group were 83.72% and69.77%.Two weeks after drug withdrawal,the clinical curative effect of experimental group and control group were90.70%and 74.41%（P〈0.05）.The time of drug withdrawal,mycology showed that the scavenging rate of experimental group and control group were 86.05% and 76.74%（P〈0.05）.Two weeks after drug withdrawal,The clearance rate of experimental group and control group were increased,（P〉0.05）.quality of life and the degree of nursing in experimental group were significantly higher than those in control group（P〈0.05）.Conclusion The treatment based on the concept of feedforward control interventions for the treatment of mucocutaneous candidiasis in voriconazole.It has important significance to improve the quality of life of patients and ensure the treatment effect.

关 键 词：前馈控制理念 伏立康唑 皮肤念珠菌病 生活质量 

分 类 号：R51[医药卫生—内科学] R75[医药卫生—临床医学]