呋塞米维持推注辅助治疗小儿重症肺炎疗效观察  

Effect of furosemide intravenous injection in the treatment of children with severe pneumonia

作　　者：钟活志[1] 贺道机[1] 叶永芝 何海燕[1] ZHONG Huo-zhi;HE Dao-ji;YE Yong-zhi;HE Hai-yan(Department of Pediatirics, the First People＇s Hospital of Zhaoqing, Zhaoqing , Guangdong 526000, Chin)

机构地区：[1]肇庆市第一人民医院儿科,广东肇庆526000

出　　处：《热带医学杂志》2018年第6期815-818,共4页Journal of Tropical Medicine

摘　　要：目的探讨呋塞米维持推注辅助治疗小儿重症肺炎的疗效及对细胞因子的影响。方法选取2015年1月-2017年1月间于本院儿科重症监护病房住院治疗的重症肺炎患儿60例,随机分为观察组和对照组,对照组行常规治疗,观察组行常规治疗联合维持推注呋塞米治疗,对比两组患儿的临床疗效,血气指标以及炎性细胞因子表达水平。结果观察组治疗有效率为96.67%,高于对照组的70.00%,差异有统计学意义(P<0.05)。两组患儿治疗前动脉氧分压(PaO_2)、二氧化碳分压(PCO_2)、动脉血氧饱和度(SaO_2)、氧合指数(PaO_2/FiO_2)以及白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)、心肌肌钙蛋白I(c Tn I)比较差异无统计学意义(P>0.05)。经治疗后两组患儿PCO_2以及IL-6、IL-8、CRP、TNF-α、c Tn I水平均显著降低,且观察组降低幅度优于对照组,差异均有统计学意义(P<0.05);而PaO_2、SaO_2、PaO_2/FiO_2均显著升高,且观察组升高幅度优于对照组,差异有统计学意义(P<0.05)。结论呋塞米维持推注辅助治疗小儿重症肺炎,可有效改善患儿呼吸道症状,降低血浆炎性因子表达水平,疗效显著。Objective To investigate the effect of furosemide intravenous injection in the treatment of children with severe pneumonia and on the cytokines expression levels.Methods 60 children with severe pneumonia were selected in PICU of our hospital from January 2015 to January 2017 and randomly divided into observation group and control group.The control group received routine treatment; the observation group received routine treatment combined with furosemide intravenous injection.The blood gas indexes,the change of the level of inflammatory cytokines and the treatment effective rate were compared between the two groups before and after treatment.Results The effective rate of the observation group was higher than that of the control group（96.67% vs.70.00%）,the difference was statistically significant（P〈0.05）.Before the treatment,there were no significant differences in partial pressure of oxygen（Pa O2）,partial pressure of carbon dioxide（PCO2）,oxygen saturation（Sa O2）,oxygenation index（Pa O2/Fi O2）,interleukin-6（IL-6）,interleukin-8（IL-8）,C-reactive protein（CRP）,tumor necrosis factor-α（TNF-α） and cardiac troponin I（c Tn I） between the two groups（P〉0.05）.After treatment,the levels of PCO2,IL-6,IL-8,CRP,TNF-α and c Tn I in the two groups decreased significantly,and the decrease in the observation group was better than that in the control group,the difference was statistically significant（P〈0.05）.The levels of Pa O2,Sa O2 and Pa O2/Fi O2 increased significantly,and the increase in the observation group was better than that in the control group（P〈0.05）.Conclusion Furosemide intravenous injection in the treatment of children with severe pneumonia had significant effect,which could effectively improve respiratory symptoms,reduce the expression levels of inflammatory factors.

关 键 词：呋塞米 小儿重症肺炎 细胞因子 

分 类 号：R725.6[医药卫生—儿科]