金丝桃苷的药理作用机制研究进展  

Advances in Pharmacological Effects of Hyperoside

作　　者：杨诗婷 王晓倩[1] 廖广辉[1] YANG Shiting;WANG Xiaoqian;LIAO Guanghui(College of Pharmaceutical Science, Zhejiang University of Traditional Chinese Medicine, Hangzhou, 311400)

机构地区：[1]浙江中医药大学药学院,杭州311400

出　　处：《中国现代应用药学》2018年第6期947-951,共5页Chinese Journal of Modern Applied Pharmacy

基　　金：浙江省重点科技创新团队自主设计项目(2010R50044-15)

摘　　要：目的对金丝桃苷抗肿瘤、抗氧化等多种药理作用机制进行综述,为金丝桃苷的进一步研究、寻找潜在治疗靶点与新药开发提供思路,为临床合理用药提供依据。方法通过大量查阅金丝桃苷相关书籍与资料,总结归纳金丝桃苷抗肿瘤、抗氧化等作用机制。结果金丝桃苷是一种重要的天然产物,广泛分布于各种植物中的果实与全草中。近年来研究发现金丝桃苷对肿瘤细胞生长具有明显的抑制作用,且能降低脑组织内的活性氧含量,发挥抗氧化作用;此外,金丝桃苷还具有良好的抗抑郁、保护心/脑缺血、保肝、免疫调节等作用。结论金丝桃苷拥有抗肿瘤、抗氧化等多种作用及较为明确的作用机制,具有广阔的发展空间。OBJECTIVE To review the pharmacological mechanism of hyperoside in anti-tumor and antioxidant, provide ideas for futher study of hyperoside finding out potential therapeutic targets and developing, so then to provide evidences for rational drug use in clinical. METHODS Through a large number of books and materials on hyperoside were reviewed to summarize its anti-tumor and antioxidant mechanisms etc. Summed up the hypericin anti-tumor mechanism and antioxidant effects. RESULTS Hypericin was an important natural product which widely distributed in the fruit of variety plants and the whole herbs. In recent years, it had been found that hyperoside could inhibit the growth of tumor cells, reduce the content of ROS in brain tissue and play an antioxidant role. In addition, hyperoside also had good performance in other aspects, such as antidepressant, heart/cerebral ischemia protection, liver preservation, immune regulation and so on. CONCLUSION Hyperin has a variety effects of anti-tumor, antioxidation etc, and its mechanism of action is clear. It has a broad development space.

关 键 词：金丝桃苷 抗肿瘤 抗氧化 作用机制 

分 类 号：R284.1[医药卫生—中药学]