河北省2016年健康人群脊髓灰质炎抗体水平分析  

Analysis of the poliomyelitis antibody level in healthy population in Hebei Province in 2016

作　　者：赵娜[1] 孙丽[1] 陈玫[1] 张俊棉[1] 郭玉[1] 郭敬云 李静[1] 朱怡青[1] 张振国[1] ZHAO Na;SUN Li;CHEN Mei;ZHANG Junmian;GUO Yu;GUO Jingyun;LI Jing;ZHU Yiqing;ZHANG Zhenguo(Hebei Center for Disease Control and Prevention, Shijiazhuang 050021 , China)

机构地区：[1]河北省疾病预防控制中心,石家庄050021

出　　处：《医学动物防制》2018年第8期777-779,782,共4页Journal of Medical Pest Control

基　　金：河北省科技计划项目(14277726D)

摘　　要：目的了解河北省2016年健康人群脊髓灰质炎(简称脊灰)中和抗体(Neutralizing Antibody,NA)水平,评价免疫效果,为维持无脊灰状态提供科学依据。方法选取河北省10个市的0~岁、1~2岁、3~4岁、5~6岁、7~14岁、15~19岁、≥20岁7个年龄组的健康人群共1 412人,用微量细胞中和实验法检测血清脊灰NA。结果Ⅰ型、Ⅲ型脊灰NA阳性率分别是96.88%、96.39%;抗体几何平均滴度(Geometric Mean Titers,GMT)分别是1∶106.11、1∶77.35。不同年龄组健康人群脊灰抗体GMT差异有统计学意义,抗体GMT随着年龄的增长有下降的趋势。结论河北省健康人群脊灰NA阳性率和GMT保持在较高水平,对脊灰已经形成牢固的免疫屏障。Objective To understand the neutralizing antibody（ NA） level of the poliomyelitis in healthy population in Hebei province in 2016,and to evaluate the effect of immunization,so as to provide scientific basis for maintaining polio-free status. Methods Seven age groups（ 0 to 1 year old,1 to 2 years old,3 to 4 years old,5 to 6 years old,7 to 14 years old,15 to19 years old and≥20 years old）,a total of 1 412 people,from healthy population in 10 cities,were selected,and the NA level of the poliomyelitis was detected with a microcell neutralization test. Results The NA positive rates for poliomyelitis I and III were 96. 88% and 96. 39% respectively,andthe geometric mean titers（ GMT） were 1 ∶ 106. 11 and 1 ∶ 77. 35 respectively. There were statistically significant differences in NA GMT of poliomyelitis among healthy people in different age groups,and the GMT decreased with aging. Conclusion The poliomyelitis NA positive rates and GMT are maintaining a high level in healthy population in Hebei Province,and a firm immune barrier has been formed against poliomyelitis.

关 键 词：脊髓灰质炎 中和抗体 健康人群 阳性率 几何平均滴度 

分 类 号：R512.4[医药卫生—内科学]