13337例梅毒病例结果分析  

Analysis of syphilis serology test results among 13 337 patients in a general hospital

作　　者：董玲娣 王文惠 刘万超 陈龙梅 DONG Lingdi;WANG Wenhui;LIU Wanchao;CHEN Longmei(Shanghai Baoshan District Traditional Chinese and Western Medicine Hospital, Shanghai201900, China)

机构地区：[1]上海市宝山区中西医结合医院,上海201900

出　　处：《医学动物防制》2018年第8期811-815,共5页Journal of Medical Pest Control

基　　金：国家科技部863计划课题组资助项目(2015AA021107);上海市宝山区中西医结合医院院级科研基金项目(院201701)

摘　　要：目的分析某院所有就诊的梅毒病人抗体检测结果,以期为梅毒的防治提供依据。方法回顾性统计上海市宝山区中西医结合医院2003年1月~2017年6月间所有梅毒病人的抗体检测结果。以梅毒螺旋体明胶颗粒凝集试验(TPPA)确诊及梅毒甲苯胺红不加热血清反应素试验(TRUST)检测效价。结果 13 337例病人接受TPPA检测,其中阳性457例,2003年1月~2017年6月TPPA阳性率分别为7.87%、6.76%、4.87%、2.40%、2.16%;门诊住院阳性率分别为7.34%、2.35%;男性与女性阳性率分别为3.40%、3.46%,其中男女差异无统计学意义(χ~2=0.039,P>0.05);≤19岁、20~39岁、40~59岁、60~79岁、80~岁组5个年龄组阳性率分别为2.34%、5.01%、4.22%、2.74%、1.98%,血清TRUST效价在1∶8及以下的各年龄组分别为66.67%、73.33%、75.68%、85.91%、97.28%。结论 TRUST转阴的比例逐年增加,梅毒防治取得一定的效果,但梅毒感染率仍然较高,有必要进一步加强梅毒防治。Objective To analyze the results of syphilis serology test among patients and to provide basis for the prevention and cure of syphilis. Methods Syphilis serology test results of patients from Jan. 2013 to Jun. 2017 in a tertiary general hospital were collected and retrospectively analyzed. The serum samples were screened by Treponema pallidum（ TP） antibody enzyme and syphilis toluidine red unheated serum test（ TRUST） simultaneously. Difference of measurement data was compared with analysis of variance. Results A total of 13 337 cases were collected,among which 457 cases were positive of anti-TP. The positive rate of anti-TP was 7. 87% in the year of 2013,6. 76% in 2014,4. 87% in 2015,2. 40% in 2016,and 2. 16% in 2017. For outpatients and inpatients,the positive rates of anti-TP were 7. 34% and 2. 35%,respectively. To the male and female patients,the positive rates of anti-TP were 3. 40% and 3. 46%,respectively（ χ^2= 0. 039,P = 0. 849）. The positive rates of anti-TP in the age groups of≤19 years,20 - 39 years,40 - b59 years,60 - 79 years,and≥80 years were 2. 34%,5. 01%,4. 22%,2. 74%,1. 98%,respectively. The anti-TP positive patients with TRUST titer 1∶ 8 accounted for 66. 67% in the age group of≤19 years,73. 33% in the 20 - 39 years group,75. 68% in the 40 - 59 years group,85. 91% in the 60 - 79 years group,and 97. 28% in the age group of≥80 years. The anti-TP positive patients with TRUST titer negative was 21. 05% in the year2013,23. 86% in 2014,35. 79% in 2015,43. 57% in 2016, and 50. 65% in 2017. Conclusion The rate of negative TRUST titer was increased by years,syphilis prevention and control achieved certain results. While the rate of syphilis infection is still high,the prevention and control measures which are necessary for syphilis should be strengthened.

关 键 词：梅毒 抗体 梅毒血清学诊断 回顾性研究 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]